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羊膜移植以减少翼状胬肉复发

Amniotic Membrane Grafts to Reduce Pterygium Recurrence.

作者信息

Rosen Ronald

机构信息

Department of Ophthalmology, Kaiser Permanente Medical Center, Panorama City, CA.

出版信息

Cornea. 2018 Feb;37(2):189-193. doi: 10.1097/ICO.0000000000001407.

Abstract

PURPOSE

To demonstrate the long-term outcome of pterygium surgery with adjunctive amniotic membrane transplantation (AMT) and intraoperative mitomycin C (MMC) in a large case series.

METHODS

Medical records were retrieved for this noncomparative retrospective study of all patients who had pterygium excision with adjunctive AMT and intraoperative MMC, from October 2010 to June 2016 with at least 6 months of follow-up.

RESULTS

There were a total of 556 eyes of 535 patients (291 males and 244 females) with average age of 51.9 ± 13 years who had pterygium excision (527 primary and 29 recurrent). For an average follow-up period of 17.3 ± 0.8 months (range 6-74 months), corneal recurrence occurred in 20 eyes (3.6%) and conjunctival recurrence in 12 (2.2%) in a total of 32 eyes (5.8%). Eleven eyes (2%) underwent reoperation. Other complications included granuloma (0.5%), diplopia (1.1%), and steroid-induced ocular hypertension (4.3%).

CONCLUSIONS

Adjunctive use of AMT and short exposure of MMC can reduce recurrence after pterygium surgery. The procedure is less tedious and less time consuming, resulting in early recovery while saving the conjunctiva for future surgeries.

摘要

目的

在一个大型病例系列中展示翼状胬肉手术联合羊膜移植(AMT)及术中使用丝裂霉素C(MMC)的长期效果。

方法

检索2010年10月至2016年6月期间所有接受翼状胬肉切除联合AMT及术中MMC治疗且随访至少6个月的患者的病历,进行这项非对照性回顾性研究。

结果

共有535例患者(291例男性和244例女性)的556只眼接受了翼状胬肉切除术(527例初发性和29例复发性),平均年龄为51.9±13岁。平均随访期为17.3±0.8个月(范围6 - 74个月),32只眼(5.8%)出现角膜复发20只眼(3.6%),结膜复发12只眼(2.2%)。11只眼(2%)接受了再次手术。其他并发症包括肉芽肿(0.5%)、复视(1.1%)和类固醇性高眼压(4.3%)。

结论

联合使用AMT及短时间应用MMC可降低翼状胬肉手术后的复发率。该手术操作不那么繁琐且耗时较少,能实现早期恢复,同时保留结膜以备未来手术使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e124/5768221/88dc482c00fc/cornea-37-189-g004.jpg

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