Bowden Jennifer A, Bowden Anton E, Wang Haonan, Hager Ron L, LeCheminant James D, Mitchell Ulrike H
Department of Exercise Sciences, Brigham Young University, Provo, Utah, 84602.
Department of Mechanical Engineering, Brigham Young University, Provo, Utah, 84602.
J Orthop Res. 2018 May;36(5):1313-1323. doi: 10.1002/jor.23765. Epub 2018 Jan 16.
Physical activity impacts health and disease in multiple body tissues including the intervertebral discs. Fluid flow within the disc is an indicator of disc health that can be observed using diffusion weighted magnetic resonance imaging. We monitored activity levels of 26 participants, age 35-55 yrs, using Actigraph accelerometers for 4 days to evaluate vigorous-intensity activity, moderate to vigorous intensity activity, and sedentary time. Participants underwent structural and diffusion weighted magnetic resonance imaging to evaluate intervertebral disc health and fluid flow. They also underwent bone density scans, carotid artery ultrasounds, a treadmill test, and a physical exam for pain, range of motion, and instability. These measures were used to correlate MRI indicators of intervertebral disc health with participant activity levels. Participants with any vigorous-intensity physical activity compared with no vigorous-intensity activity had significantly greater L5/S1 apparent diffusion coefficient values (p = 0.002), corresponding to higher freedom of diffusive movement for cellular nutrients and metabolic waste. Sagittal T2 values in the L5/S1 were also higher (p = 0.004), corresponding to a higher water content in the discs. Higher apparent diffusion coefficients were also found in participants with more than 30 min compared with less than 30 min of daily moderate to vigorous physical activity (p = 0.03), and in participants with less than 67% awake time as sedentary time compared with more than 67% sedentary time (p = 0.03). Increased dynamic loading through physical activity and decreased static loading from sedentary time benefit intervertebral disc health. Physical activity, particularly vigorous activity, is beneficial in helping maintain intervertebral disc health. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1313-1323, 2018.
身体活动会对包括椎间盘在内的多个身体组织的健康和疾病产生影响。椎间盘内的液体流动是椎间盘健康的一个指标，可通过扩散加权磁共振成像进行观察。我们使用Actigraph加速度计对26名年龄在35 - 55岁之间的参与者的活动水平进行了4天的监测，以评估剧烈强度活动、中度至剧烈强度活动和久坐时间。参与者接受了结构和扩散加权磁共振成像，以评估椎间盘健康和液体流动情况。他们还进行了骨密度扫描、颈动脉超声检查、跑步机测试以及针对疼痛、活动范围和不稳定性的体格检查。这些测量用于将椎间盘健康的MRI指标与参与者的活动水平相关联。与没有剧烈强度活动的参与者相比，有任何剧烈强度身体活动的参与者的L5/S1表观扩散系数值显著更高（p = 0.002），这对应于细胞营养物质和代谢废物扩散运动的更高自由度。L5/S1的矢状面T2值也更高（p = 0.004），这对应于椎间盘更高的含水量。与每天中度至剧烈身体活动少于30分钟的参与者相比，每天中度至剧烈身体活动超过30分钟的参与者也有更高的表观扩散系数（p = 0.03），并且与久坐时间超过67%的参与者相比，久坐时间少于67%清醒时间的参与者也有更高的表观扩散系数（p = 0.03）。通过身体活动增加动态负荷以及减少久坐时间的静态负荷有利于椎间盘健康。身体活动，尤其是剧烈活动，有助于维持椎间盘健康。© 2017骨科学研究协会。由威利期刊公司出版。《矫形外科学研究》36:1313 - 1323，2018年。
