Fujita Toshiko, Shirasawa Takuji, Inoue Haruhiko, Kitamura Tsuneo, Maruyama Naoki
Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo.
Department of Molecular Genetics, Tokyo Metropolitan Institute of Gerontology, Tokyo.
J Gastroenterol Hepatol. 1998 Sep;13(S1):S124-S131. doi: 10.1111/jgh.1998.13.s1.124.
A novel rat hepatic protein was detected and isolated, the amount of which is down-regulated in an androgen-independent manner with ageing. This protein was designated as senescence marker protein-30 (SMP30). Senescence marker protein-30 turned out to be identical to a hepatic calcium-binding protein called regucalcin (RC). This review gives an overview of SMP30 in its structure, expression and possible physiological function(s). A hypothetical role of SMP30 in ageing and calcium homeostasis is also discussed.
一种新的大鼠肝脏蛋白被检测并分离出来，其含量随着衰老以雄激素非依赖的方式下调。这种蛋白被命名为衰老标记蛋白-30（SMP30）。结果表明，衰老标记蛋白-30与一种名为调钙素（RC）的肝脏钙结合蛋白相同。本文综述了SMP30的结构、表达及其可能的生理功能。还讨论了SMP30在衰老和钙稳态中的假设作用。
