Okonkwo Ikechukwu, Ibadin Michael, Sadoh Wilson, Omoigberale Austine
Department of Child Health, University of Benin Teaching Hospital, Benin City, 30001, Nigeria.
Department of Child Health, University of Benin, Benin City, 30001, Nigeria.
J Trop Pediatr. 2018 Aug 1;64(4):289-296. doi: 10.1093/tropej/fmx065.
Human immunodeficiency virus (HIV) and malaria are leading causes of morbidity and mortality among under-fives in sub-Saharan Africa. HIV infection could affect development of antimalarial immunity by impaired parasite clearance with predisposition to higher malaria parasitaemia.
The objective of this study is to assess asymptomatic malaria parasite density (AMPD) in HIV-1-infected under-fives in a holoendemic zone.
HIV-1-positive and -negative children <5 years on follow-up care were recruited and AMPD and CD4 counts were determined.
A total of 358 children were studied. Significantly higher malaria parasitaemia was found in HIV-infected individuals (118.7 vs. 87.3 parasite/μl, p = 0.021). Disparity in AMPD was most pronounced at infancy with similar distribution at all age brackets and consistently higher parasitaemia in the subjects.
Parasitaemia is higher in HIV-infected than uninfected children. The burden is highest at infancy. Acquisition of antimalarial immunity is similar in both groups. Parasitaemia is not significantly affected by clinical disease stage or worsening immunosuppression.
人类免疫缺陷病毒（HIV）和疟疾是撒哈拉以南非洲5岁以下儿童发病和死亡的主要原因。HIV感染可能通过损害寄生虫清除能力并导致更高的疟疾寄生虫血症，从而影响抗疟免疫力的发展。
本研究的目的是评估全流行区感染HIV-1的5岁以下儿童的无症状疟疾寄生虫密度（AMPD）。
招募接受随访护理的5岁以下HIV-1阳性和阴性儿童，并测定AMPD和CD4计数。
共研究了358名儿童。在HIV感染个体中发现疟疾寄生虫血症明显更高（118.7对87.3个寄生虫/μl，p = 0.021）。AMPD的差异在婴儿期最为明显，在所有年龄段分布相似，且受试者的寄生虫血症一直较高。
HIV感染儿童的寄生虫血症高于未感染儿童。负担在婴儿期最高。两组的抗疟免疫力获得情况相似。寄生虫血症不受临床疾病阶段或免疫抑制恶化的显著影响。
