Garg Bhawan Deep, Bajaj Naveen, Sharma Deepak
Deep hospital, Ludhiana, Punjab, India.
Department of Neonatology, National Institute of Medical Sciences, Jaipur, Rajasthan, India.
J Trop Pediatr. 2018 Aug 1;64(4):262-266. doi: 10.1093/tropej/fmx057.
The objective of this study was to compare efficacy of continuous positive airway pressure (CPAP) and heated humidified high-flow nasal cannula (HHHFNC) as noninvasive respiratory support in post-extubation period in very low birth weight (VLBW) infants.
This retrospective study enrolled 136 neonates, ≤32 weeks gestation and ≤1500 grams birth weight, requiring noninvasive respiratory support during post-extubation period.
There was no significant difference in post-extubation failure in HHHFNC group when compared with CPAP group (p > 0.05) but post-extubation complication was significantly higher in CPAP group (p < 0.05) including nasal septal trauma and pneumothorax.
In neonates ≤32 weeks of gestational age, HHHFNC showed similar efficacy, and better safety profile than nasal-CPAP when used during post-extubation period for respiratory support.
本研究的目的是比较持续气道正压通气（CPAP）和温热湿化高流量鼻导管（HHHFNC）作为极低出生体重（VLBW）婴儿拔管后无创呼吸支持的疗效。
这项回顾性研究纳入了136例孕周≤32周、出生体重≤1500克且在拔管后需要无创呼吸支持的新生儿。
与CPAP组相比，HHHFNC组拔管失败无显著差异（p>0.05），但CPAP组拔管后并发症显著更高（p<0.05），包括鼻中隔创伤和气胸。
在孕周≤32周的新生儿中，HHHFNC在拔管后用于呼吸支持时显示出相似的疗效，且安全性优于鼻CPAP。
