Zhao Yuming, Zhong Shengyi, Li Zhenhua, Zhu Xiaofeng, Wu Feima, Li Yanxing
Department of Cardiothoracic Surgery, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning 437100, China.
Oncotarget. 2017 Jul 15;8(37):62231-62239. doi: 10.18632/oncotarget.19258. eCollection 2017 Sep 22.
The positive lymph node ratio (LNR) has been suggested as a predictor of survival in patients with esophageal carcinoma (EC). However, existed evidences did not completely agree with each other. We sought to examine whether LNR was associated with overall survival (OS). Electronic database was searched for eligible literatures. The primary outcome was the relationship between LNR and OS, which was presented as hazard ratio (HR) with 95% confidence intervals (CIs). All statistical analyses were performed using STATA 11.0 software. A total of 18 relevant studies which involved 7,664 cases were included. Patients with an LNR of 0.3 or greater had an increased risk of death compared to those with an LNR of less than 0.3(HR = 2.33; 95% CI 2.03-2.68; P<0.01). Similarly, patients with an LNR greater than 0.5 was also associated with a decreased OS(HR = 1.95; 95% CI 1.52-2.50; P<0.01). No publication bias was found. This meta-analysis confirmed that LNR was a significant predictor of survival in patients with EC and should be considered in prognostication.
阳性淋巴结比率（LNR）已被认为是食管癌（EC）患者生存的一个预测指标。然而，现有证据并不完全一致。我们试图研究LNR是否与总生存期（OS）相关。通过检索电子数据库查找符合条件的文献。主要结局是LNR与OS之间的关系，以风险比（HR）及95%置信区间（CI）表示。所有统计分析均使用STATA 11.0软件进行。共纳入18项相关研究，涉及7664例患者。与LNR小于0.3的患者相比，LNR为0.3或更高的患者死亡风险增加（HR = 2.33；95%CI 2.03 - 2.68；P<0.01）。同样，LNR大于0.5的患者OS也降低（HR = 1.95；95%CI 1.52 - 2.50；P<0.01）。未发现发表偏倚。这项荟萃分析证实，LNR是EC患者生存的一个重要预测指标，在预后评估中应予以考虑。
