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Prognostic role of the lymph node ratio in node positive colorectal cancer: a meta-analysis.

作者信息

Zhang Ming-Ran, Xie Tian-Hang, Chi Jun-Lin, Li Yuan, Yang Lie, Yu Yong-Yang, Sun Xiao-Feng, Zhou Zong-Guang

机构信息

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.

Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Oncotarget. 2016 Nov 8;7(45):72898-72907. doi: 10.18632/oncotarget.12131.

DOI:10.18632/oncotarget.12131
PMID:27662659
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5341952/
Abstract

The lymph node ratio (LNR) (i.e. the number of metastatic lymph nodes divided by the number of totally resected lymph nodes) has recently emerged as an important prognostic factor in colorectal cancer (CRC). However, the tumor node metastasis (TNM) staging system for colorectal cancer does not consider it as a prognostic parameter. Therefore, we conducted a meta-analysis to evaluate the prognostic role of the LNR in node positive CRC. A systematic search was performed in PubMed, Embase and the Cochrane Library for relevant studies up to November 2015. As a result, a total of 75,838 node positive patients in 33 studies were included in this meta-analysis. Higher LNR was significantly associated with shorter overall survival (OS) (HR = 1.91; 95% CI 1.71-2.14; P = 0.0000) and disease free survival (DFS) (HR = 2.75; 95% CI: 2.14-3.53; P = 0.0000). Subgroup analysis showed similar results. Based on these results, LNR was an independent predictor of survival in colorectal cancer patients and should be considered as a parameter in future oncologic staging systems.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/46b44eb28629/oncotarget-07-72898-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/dceddb5a5853/oncotarget-07-72898-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/b9ebf913adfa/oncotarget-07-72898-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/0c16e2d131a9/oncotarget-07-72898-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/c14b928111c3/oncotarget-07-72898-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/46b44eb28629/oncotarget-07-72898-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/dceddb5a5853/oncotarget-07-72898-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/b9ebf913adfa/oncotarget-07-72898-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/0c16e2d131a9/oncotarget-07-72898-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/c14b928111c3/oncotarget-07-72898-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e72/5341952/46b44eb28629/oncotarget-07-72898-g005.jpg

相似文献

[1]
Prognostic role of the lymph node ratio in node positive colorectal cancer: a meta-analysis.

Oncotarget. 2016-11-8

[2]
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[3]
Integrated analysis of the prognostic role of the lymph node ratio in node-positive gastric cancer: A meta-analysis.

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[4]
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[5]
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[6]
Prognostic value of lymph node ratio in stage III colorectal cancer.

Colorectal Dis. 2011-10

[7]
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Tumour Biol. 2014-11

[8]
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Ann Surg. 2010-6

[9]
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Ann Surg Oncol. 2015-5

[10]
Regional Lymph Nodes Status and Ratio of Metastatic to Examined Lymph Nodes Correlate with Survival in Stage IV Colorectal Cancer.

Ann Surg Oncol. 2016-7

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[5]
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[6]
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[7]
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World J Gastrointest Oncol. 2024-5-15

[8]
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Diagn Pathol. 2024-2-28

[9]
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Front Oncol. 2024-2-7

[10]
Effects of magnetic resonance imaging (MRI)-detected extramural vascular invasion (mrEMVI) and tumor deposits (TDs) on distant metastasis and long-term survival after surgery for stage III rectal cancer: a retrospective study grouped based on the relationship between the bottom of the tumor and peritoneal reflection.

J Gastrointest Oncol. 2023-4-29

本文引用的文献

[1]
Lymph node ratio may predict the benefit of postoperative radiotherapy in node-positive cervical cancer.

Oncotarget. 2016-5-17

[2]
Extranodal extension is an important prognostic parameter for both colonic and rectal cancer.

Ann Oncol. 2016-5

[3]
Prognostic impact and implications of extracapsular lymph node involvement in colorectal cancer: a systematic review with meta-analysis.

Ann Oncol. 2015-10-19

[4]
Lymph node ratio is a prognostic factor for non-small cell lung cancer.

Oncotarget. 2015-10-20

[5]
Prognostic value of lymph node ratio and extramural vascular invasion on survival for patients undergoing curative colon cancer resection.

Br J Cancer. 2015-7-14

[6]
Prognostic value of lymph node ratio in survival of patients with locally advanced rectal cancer.

Can J Surg. 2015-8

[7]
Metastatic lymph node ratio successfully predicts prognosis in western gastric cancer patients.

Surg Oncol. 2015-6

[8]
Importance of metastatic lymph node ratio in non-metastatic, lymph node-invaded colon cancer: a clinical trial.

Med Sci Monit. 2014-8-4

[9]
The prognostic impact of the log odds of positive lymph nodes in colon cancer.

Colorectal Dis. 2014-11

[10]
A new prognostic strategy for gastric carcinoma: albumin level and metastatic lymph node ratio.

Minerva Chir. 2014-6

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