Zeng Wei, Ren Xiaohui, Cui Yong, Jiang Haihui, Zhang Xiuru, Lin Song
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
Oncotarget. 2017 May 16;8(40):67104-67116. doi: 10.18632/oncotarget.17947. eCollection 2017 Sep 15.
Recently, we reported that 1q/19p co-polysomy predicted poor prognosis in oligodendroglial tumors. In this study, we aimed to retrospectively analyze the prognostic significance of 1q/19p polysomy in two large cohorts of astrocytic gliomas classified by the 2007 and 2016 WHO classification of tumors of the central nervous system. 1q/19p polysomy was detected using the FISH method, and factors that correlated with polysomy were analyzed by logistic regression. Survival analysis was used to identify independent prognostic factors correlated with survival. In the WHO astrocytic glioma cohort (N=421), co-polysomy was associated with a younger age, whereas single polysomy was associated with higher tumor grades and a higher Ki-67 index (<0.05). Co-polysomy predicted longer survival, and single polysomy predicted shorter survival (<0.05). In multivariate analysis, co-polysomy maintained an independent prognostic impact on survival (=0.001) after adjustment for age, KPS, grade, removal degree, tumor size, Ki-67 index, and IDH1/2. In the WHO cohort (N=572), we validated the prognostic merit of co-polysomy after adjusting for related factors. In conclusion, 1q/19p co-polysomy added prognostic information in cases of astrocytic glioma and could be used for molecular stratification of this disease.
最近，我们报道了1q/19p共多体性预测少突胶质细胞瘤预后不良。在本研究中，我们旨在回顾性分析1q/19p多体性在根据2007年和2016年世界卫生组织中枢神经系统肿瘤分类划分的两个大型星形细胞瘤队列中的预后意义。采用荧光原位杂交（FISH）方法检测1q/19p多体性，并通过逻辑回归分析与多体性相关的因素。生存分析用于确定与生存相关的独立预后因素。在世界卫生组织星形细胞瘤队列（N = 421）中，共多体性与较年轻的年龄相关，而单多体性与较高的肿瘤分级和较高的Ki-67指数相关（<0.05）。共多体性预测生存期较长，单多体性预测生存期较短（<0.05）。在多变量分析中，在对年龄、KPS、分级、切除程度、肿瘤大小、Ki-67指数和异柠檬酸脱氢酶1/2（IDH1/2）进行调整后，共多体性对生存仍具有独立的预后影响（=0.001）。在世界卫生组织队列（N = 572）中，我们在对相关因素进行调整后验证了共多体性的预后价值。总之，1q/19p共多体性为星形细胞瘤病例增加了预后信息，可用于该疾病的分子分层。
