失去平衡：癌症中非整倍体的起源和影响。
Losing balance: the origin and impact of aneuploidy in cancer.
机构信息
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0670, USA.
出版信息
EMBO Rep. 2012 Jun 1;13(6):501-14. doi: 10.1038/embor.2012.55.
Abstract
Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.
摘要
大多数实体人类肿瘤是非整倍体的，也就是说，它们含有异常数量的染色体。然而，矛盾的是，非整倍体已被报道会诱导一种应激反应，从而抑制体外细胞增殖。在这里，我们综述了人们对癌症中非整倍体的原因和影响的认识进展，并讨论了在特定情况下，非整倍体如何提供生长优势并促进细胞转化。我们还探讨了针对非整倍体的原因或后果进行治疗的新可能性。
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