TREM2：在顺境与逆境中保持小胶质细胞的健康。
TREM2: Keeping Microglia Fit during Good Times and Bad.
机构信息
F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
出版信息
Cell Metab. 2017 Oct 3;26(4):590-591. doi: 10.1016/j.cmet.2017.09.010.
Microglia are the macrophages of the brain and play an important role in Alzheimer's disease (AD). In Cell, Ulland et al. (2017) recently reported that mutations in TREM2, a protein implicated in AD, disrupt microglial energy state and function, thus sabotaging the microglia's ability to defend the brain against amyloid plaques.
小胶质细胞是大脑中的巨噬细胞，在阿尔茨海默病（AD）中发挥重要作用。在《细胞》杂志上，Ulland 等人（2017 年）最近报道称，TREM2 蛋白（与 AD 相关的蛋白）突变会破坏小胶质细胞的能量状态和功能，从而破坏小胶质细胞防御大脑免受淀粉样斑块侵害的能力。
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