Berndtson W E, Hoyer J H, Squires E L, Pickett B W
J Reprod Fertil Suppl. 1979(27):19-23.
The effect of exogenous testosterone on sperm production, seminal quality and libido was studied in 24 stallions. Based on pretreatment data, a stallion was assigned to 1 of 3 groups each containing 8 animals. One member of each group received 0 (Group 1), 50 (Group 2), or 200 micrograms (Group 3) testosterone propionate per kg body weight every 2 days for 88 days. The lower dose of testosterone had no significant effect on most of the parameters studied: the higher dose depressed total scrotal width at Day 90 post-treatment (P less than 0.01), total spermatozoa ejaculated between Days 60 and 90 (P less than 0.01) and 96 progressively motile spermatozoa between Days 60 and 90 (P less than 0.10). One half of the stallions from each treatment were castrated on Day 90. In the operated stallions, the mean number of spermatids per g testicular parenchyma in the controls (Group 1) was significantly (P less than 0.05) higher than that in Group 3 whereas the difference between the number of spermatids/testis in the same stallions of these two groups was significant only at P less than 0.1. Testosterone propionate treatment did not influence time to erection, interval from first mount to ejaculation or number of mounts per ejaculation. The treatment of normal, intact stallions with testosterone propionate did not enhance libido and caused a severe depression of reproductive capacity.
在24匹种马中研究了外源性睾酮对精子生成、精液质量和性欲的影响。根据预处理数据,将一匹种马分配到3组中的1组,每组有8只动物。每组中的一只种马每2天接受0(第1组)、50(第2组)或200微克(第3组)每千克体重的丙酸睾酮,持续88天。较低剂量的睾酮对大多数研究参数没有显著影响:较高剂量在治疗后第90天降低了总阴囊宽度(P<0.01),在第60天至90天期间射出的总精子数(P<0.01)以及在第60天至90天期间96条渐进性活动精子数(P<0.10)。每组治疗的一半种马在第90天进行去势。在接受手术的种马中,对照组(第1组)每克睾丸实质的精子细胞平均数显著高于第3组(P<0.05),而这两组相同种马的每个睾丸精子细胞数差异仅在P<0.1时显著。丙酸睾酮治疗不影响勃起时间、从首次爬跨到射精的间隔或每次射精的爬跨次数。用丙酸睾酮治疗正常、未阉割的种马不会增强性欲,反而会导致生殖能力严重下降。