Nayler W G
Department of Medicine, University of Melbourne, Heidelberg, Victoria.
Drugs. 1988;35 Suppl 4:1-8. doi: 10.2165/00003495-198800354-00003.
Whereas the beta-blockers were heralded as the drugs of the sixties and early seventies, the calcium antagonists have established themselves as the drugs of the eighties. However, despite the widely differing pharmacology of these 2 classes of drugs, they are often used for the management of the same cardiovascular disorders, including angina pectoris, ischaemic heart disease and hypertension. Whether some advantage might be gained from their combined use depends upon a precise understanding of how these drugs interact with the cardiovascular system. It also requires a clear recognition of the different pharmacological profiles displayed by individual members of the same class of drugs.
β受体阻滞剂曾被誉为六七十年代的药物，而钙拮抗剂已确立其作为八十年代药物的地位。然而，尽管这两类药物的药理学差异很大，但它们常常用于治疗相同的心血管疾病，包括心绞痛、缺血性心脏病和高血压。联合使用这两类药物是否能带来某些益处，取决于对这些药物如何与心血管系统相互作用的精确理解。这还需要清楚认识同一类药物中各个成员所表现出的不同药理学特征。
