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东莨菪碱对用氟哌啶醇或 SCH 23390 处理的大鼠的阿扑吗啡诱导行为有调节作用。

Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390.

作者信息

Butkerait P, Friedman E

机构信息

Department of Psychiatry, Medical College of Pennsylvania/EPPI, Philadelphia 19129.

出版信息

Eur J Pharmacol. 1988 Mar 29;148(2):269-72. doi: 10.1016/0014-2999(88)90573-0.

Abstract

In acute experiments, scopolamine (1.0 mg/kg) potentiated apomorphine stereotypy and inhibited the antistereotypic effect of both haloperidol (0.5 mg/kg) and SCH 23390 (0.2 mg/kg). Daily administration of either haloperidol (0.5 mg/kg) or SCH 23390 (0.2 mg/kg) for 3 weeks produced enhanced stereotypic responses to apomorphine. Co-administration of scopolamine (1.0 mg/kg) with haloperidol or SCH 23390 significantly reduced the behavioral supersensitivity produced by haloperidol or SCH 23390 alone. It is suggested that both D-1 and D-2 dopamine receptors are linked to a cholinergic mechanism.

摘要

在急性实验中,东莨菪碱(1.0毫克/千克)增强了阿扑吗啡引起的刻板行为,并抑制了氟哌啶醇(0.5毫克/千克)和SCH 23390(0.2毫克/千克)的抗刻板行为作用。每日给予氟哌啶醇(0.5毫克/千克)或SCH 23390(0.2毫克/千克),持续3周,会增强对阿扑吗啡的刻板反应。将东莨菪碱(1.0毫克/千克)与氟哌啶醇或SCH 23390联合使用,可显著降低单独使用氟哌啶醇或SCH 23390所产生的行为超敏反应。提示D-1和D-2多巴胺受体均与胆碱能机制相关。

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