Bender K I, Lutsevich A N, Lutsevich I N
Farmakol Toksikol. 1988 Mar-Apr;51(2):85-8.
It was shown by the in situ method that absorption of dimedrol, pipolphen and suprastine from the small intestine of the rats immunized parenterally with ovalbumin against the background of intravenous administration of the resolving dose of ovalbumin significantly decreased in connection with the formation in the immunized rats of antiovalbumin antibodies. Administration of euphylline simultaneously with the resolving dose of ovalbumin to the immunized rats partially normalized absorbability of all three drugs.
原位法显示,在静脉注射溶解剂量卵清蛋白的背景下,经卵清蛋白非肠道免疫的大鼠,其小肠对苯海拉明、异丙嗪和氯苯那敏的吸收,因免疫大鼠体内抗卵清蛋白抗体的形成而显著降低。在给免疫大鼠静脉注射溶解剂量卵清蛋白的同时给予氨茶碱,可使这三种药物的吸收能力部分恢复正常。