Lane Andrew S, Champion Bernard, Orde Sam, Dravec Danijela
Sydney Medical School, Sydney, NSW, Australia.
Nepean Hospital, Sydney, NSW, Australia.
J Intensive Care Soc. 2015 Feb;16(1):64-70. doi: 10.1177/1751143714551249. Epub 2014 Dec 10.
Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D), which without treatment leads to death. Fulminant type 1 diabetes (FT1D) is a subtype characterised by a markedly rapid and almost complete destruction of pancreatic β-cells, with acute onset leading to severe metabolic derangement and commonly ICU admission. We present a case of an 18-year-old male presenting with FT1D with two rare complications of pneumomediastinum and stress-induced cardiomyopathy (SIC) with significant myocardial necrosis. We also discuss the aetiology of the pneumomediastinum; the latest thoughts on SIC: moving beyond the simple description of 'Takotsubo cardiomyopathy'; the role of troponins in critical illness; and genetic predisposition for DKA due to FT1D.
糖尿病酮症酸中毒(DKA)是1型糖尿病(T1D)的一种危及生命的并发症,如不治疗会导致死亡。暴发性1型糖尿病(FT1D)是一种亚型,其特征是胰腺β细胞明显快速且几乎完全被破坏,急性起病导致严重的代谢紊乱,患者通常需入住重症监护病房(ICU)。我们报告一例18岁男性患者,患有FT1D,并伴有纵隔气肿和应激性心肌病(SIC)这两种罕见并发症,且存在明显的心肌坏死。我们还讨论了纵隔气肿的病因;关于SIC的最新观点:超越对“应激性心肌病”的简单描述;肌钙蛋白在危重病中的作用;以及FT1D所致DKA的遗传易感性。