Ludwig Parker E, Patil Arun A, Chamczuk Andrea J, Agrawal Devendra K
Department of Clinical and Translational Science, Creighton University School of MedicineOmaha, NE, USA.
Department of Neurosurgery, Creighton University School of MedicineOmaha, NE, USA.
Am J Transl Res. 2017 Sep 15;9(9):3881-3895. eCollection 2017.
Traumatic spinal cord injuries are major health problems and the underlying pathophysiological events and treatment strategies are currently under investigation. In this article, we critically reviewed the literature investigating the effects of estrogen, progesterone, and human chorionic gonadotropin on spinal cord damage or preservation following traumatic spinal cord injury. The National Library of Medicine database was searched through December 2016 using PubMed for articles addressing the clinical relevance of the hormones to improve neural structural integrity following traumatic spinal cord injury. It was found that each of these hormones, through varied mechanisms, could serve to reduce the harmful effects associated with spinal cord injury, and could aid in restoring some function to the injured spinal cord in the animal models. The most striking effects were seen in the reduction of inflammation commonly linked to injury of the central nervous system. The effects of human chorionic gonadotropin administration following spinal cord injury have received far less attention than those of either estrogen or progesterone, and additional inquiry could be of general benefit. In this article, we discussed the outstanding questions and suggested future directions for further investigation.
创伤性脊髓损伤是重大的健康问题，目前正在对其潜在的病理生理事件和治疗策略进行研究。在本文中，我们批判性地回顾了有关雌激素、孕酮和人绒毛膜促性腺激素对创伤性脊髓损伤后脊髓损伤或保护作用影响的文献。通过美国国立医学图书馆数据库，利用PubMed检索截至2016年12月探讨这些激素对改善创伤性脊髓损伤后神经结构完整性的临床相关性的文章。结果发现，这些激素中的每一种通过不同机制，都可以减少与脊髓损伤相关的有害影响，并有助于在动物模型中使受损脊髓恢复一些功能。最显著的效果是在减少通常与中枢神经系统损伤相关的炎症方面。与雌激素或孕酮相比，脊髓损伤后人绒毛膜促性腺激素给药的效果受到的关注要少得多，进一步的研究可能会带来普遍益处。在本文中，我们讨论了悬而未决的问题，并提出了未来进一步研究的方向。
