GRHL2通过调控RhoG的转录活性抑制非小细胞肺癌的肿瘤转移。
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
作者信息
Pan Xiang, Zhang Rong, Xie Caifeng, Gan Mingxi, Yao Sheng, Yao Yubin, Jin Jiangbo, Han Tianyu, Huang Yunhe, Gong Yanlong, Wang Jianbin, Yu Bentong
机构信息
Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang UniversityJiangxi 330006, China.
Department of Health, The First Affiliated Hospital of Nanchang UniversityJiangxi 330006, China.
出版信息
Am J Transl Res. 2017 Sep 15;9(9):4217-4226. eCollection 2017.
The transcription factor, Grainyhead-like 2 (GRHL2), is involved in wound healing, epidermal integrity, and epithelial-to-mesenchymal transition (EMT) in various biological processes; however, the biological function of GRHL2 in non-small cell lung cancer (NSCLC) is unknown. In the current study, we investigated the effect of GRHL2 on cell growth and migration in NSCLC cell lines and clinical tissues. Immunohistochemical analysis of clinical NSCLC specimens revealed that patients with high GRHL2 expression were associated with poor prognosis compared to patients with low GRHL2 expression. GRHL2 overexpression promoted cell growth and colony formation, and simultaneously suppressed cell migration in NSCLC cells. Furthermore, GRHL2 decreased the transcriptional activity of RhoG by directly binding to the RhoG promoter region. These findings confirm that GRHL2 plays an important role in regulating cell proliferation and migration in NSCLC.
转录因子颗粒头样蛋白2（GRHL2）参与多种生物学过程中的伤口愈合、表皮完整性和上皮-间质转化（EMT）；然而，GRHL2在非小细胞肺癌（NSCLC）中的生物学功能尚不清楚。在本研究中，我们调查了GRHL2对NSCLC细胞系和临床组织中细胞生长和迁移的影响。对临床NSCLC标本的免疫组织化学分析显示，与GRHL2低表达患者相比，GRHL2高表达患者的预后较差。GRHL2过表达促进NSCLC细胞的生长和集落形成，同时抑制细胞迁移。此外，GRHL2通过直接结合RhoG启动子区域降低其转录活性。这些发现证实GRHL2在调节NSCLC细胞增殖和迁移中起重要作用。
Zotero 插件