代谢过程和细胞内信号通路诱导的上皮-间质转化（EMT）对实体瘤化疗耐药性、转移和复发的影响。

Liaghat Mahsa, Ferdousmakan Saeid, Mortazavi Seyedeh Haniyeh, Yahyazadeh Sheida, Irani Asrin, Banihashemi Sara, Seyedi Asl Fatemeh Sadat, Akbari Abdullatif, Farzam Farnoosh, Aziziyan Fatemeh, Bakhtiyari Maryam, Arghavani Mohammad Javad, Zalpoor Hamidreza, Nabi-Afjadi Mohsen

Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran.

Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran.

Cell Commun Signal. 2024 Dec 2;22(1):575. doi: 10.1186/s12964-024-01957-4.

The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor cell invasion, metastasis, drug resistance, and recurrence. So, a better understanding of the intricate processes underlying EMT and its role in tumor growth may lead to the development of novel therapeutic approaches for the treatment of solid tumors. This review article focuses on the signals that promote EMT and metabolism, the intracellular signaling pathways leading to EMT, and the network of interactions between EMT and cancer cell metabolism. Furthermore, the functions of EMT in treatment resistance, recurrence, and metastasis of solid cancers are covered. Lastly, treatment approaches that focus on intracellular signaling networks and metabolic alterations brought on by EMT will be discussed.

这种复杂的细胞过程，即上皮-间质转化（EMT），对实体瘤的发展有重大影响。与EMT相关的细胞形状、代谢和基因表达的变化促进了肿瘤细胞的侵袭、转移、耐药性和复发。因此，更好地理解EMT背后的复杂过程及其在肿瘤生长中的作用，可能会催生治疗实体瘤的新型治疗方法。这篇综述文章重点关注促进EMT和代谢的信号、导致EMT的细胞内信号通路，以及EMT与癌细胞代谢之间的相互作用网络。此外，还涵盖了EMT在实体癌的治疗抵抗、复发和转移中的作用。最后，将讨论针对EMT引起的细胞内信号网络和代谢改变的治疗方法。