分泌生长抑素的胰岛细胞瘤（生长抑素瘤）：生长激素释放激素诱导的生长激素（GH）释放受抑制。

Somatostatin-secreting islet cell tumor (somatostatinoma): suppression of growth hormone (GH) release induced by GH-releasing hormone.

作者信息

Iguchi H, Kumagai S, Seo I H, Wakasugi H, Hara Y, Abe M

机构信息

Department of Biochemistry, National Kyushu Cancer Center, Fukuoka, Japan.

出版信息

J Clin Endocrinol Metab. 1988 Jul;67(1):206-10. doi: 10.1210/jcem-67-1-206.

DOI:10.1210/jcem-67-1-206

PMID:2897973

Abstract

A patient with a somatostatin (SRIH)-secreting islet cell tumor, whose only symptoms were dyspepsia and anemia, is described. The diagnosis of somatostatinoma was based on high plasma SRIH concentrations and immunocytochemical findings. The pancreatic exocrine response to secretin was decreased, whereas the insulin and/or glucagon responses to glucose and arginine were normal. Although the basal plasma GH concentration was normal, the plasma GH response to GHRH was subnormal. Gel permeation chromatography studies indicated that SRIH-14 was the predominant form of SRIH in plasma as well as in tumor tissue.

摘要

本文描述了一名患有分泌生长抑素（SRIH）的胰岛细胞瘤患者，其唯一症状为消化不良和贫血。生长抑素瘤的诊断基于高血浆SRIH浓度和免疫细胞化学检查结果。对促胰液素的胰腺外分泌反应降低，而对葡萄糖和精氨酸的胰岛素和/或胰高血糖素反应正常。尽管基础血浆生长激素（GH）浓度正常，但血浆GH对生长激素释放激素（GHRH）的反应低于正常水平。凝胶渗透色谱研究表明，SRIH-14是血浆以及肿瘤组织中SRIH的主要形式。