五种α受体阻滞剂对犬下尿路腹下神经刺激的影响。
Effects of five alpha-blockers on the hypogastric nerve stimulation of the canine lower urinary tract.
作者信息
Poirier M, Riffaud J P, Lacolle J Y, Dupont C
机构信息
Département de Pharmacologie, Laboratoires DEBAT, Garches, France.
出版信息
J Urol. 1988 Jul;140(1):165-7. doi: 10.1016/s0022-5347(17)41519-9.
PMID:2898024
Abstract
Electrical stimulation of the hypogastric nerve increased both urethral and bladder pressures of anaesthetized male dogs, without affecting cardiovascular parameters. Intravenous injections of prazosin, phentolamine, thymoxamine, phenoxybenzamine and yohimbine inhibited the urethral pressure increase in a dose-dependent manner, but the increase in bladder pressure was not modified by these alpha-blockers.
摘要
对麻醉的雄性犬的腹下神经进行电刺激，可使尿道和膀胱压力均升高，而不影响心血管参数。静脉注射哌唑嗪、酚妥拉明、噻吗洛尔、酚苄明和育亨宾可剂量依赖性地抑制尿道压力升高，但这些α受体阻滞剂对膀胱压力升高无影响。
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