估计不平衡系数。

Estimating Disequilibrium Coefficients.

作者信息

Vens Maren, Ziegler Andreas

机构信息

Institut für Medizinische Biometrie und Epidemiologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, Hamburg, 20246, Germany.

Institut für Medizinische Biometrie und Statistik & Zentrum für klinische Studien, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, Lübeck, 23562, Germany.

出版信息

Methods Mol Biol. 2017;1666:117-132. doi: 10.1007/978-1-4939-7274-6_7.

DOI:10.1007/978-1-4939-7274-6_7

PMID:28980244

Abstract

Gametic phase disequilibrium is the nonrandom association of alleles within gametes. Linkage disequilibrium (LD) describes the special case of deviation from independence between alleles at two linked genetic loci. Estimation of allelic LD requires knowledge of haplotypes. Genotype-based LD measures dispense with the haplotype estimation step and avoid bias in LD estimation. In this chapter, the most important measures for allelic and genotypic LD are introduced. The use of software packages for LD estimation is illustrated.

摘要

配子相不平衡是指配子内等位基因的非随机关联。连锁不平衡（LD）描述了两个连锁基因座上等位基因之间偏离独立性的特殊情况。等位基因LD的估计需要单倍型的知识。基于基因型的LD测量方法无需单倍型估计步骤，可避免LD估计中的偏差。在本章中，将介绍等位基因和基因型LD的最重要测量方法，并说明用于LD估计的软件包的使用。