Hulman G
Department of Histopathology, Royal Marsden Hospital, Sutton.
Lancet. 1988 Jun 18;1(8599):1366-7. doi: 10.1016/s0140-6736(88)92182-4.
Like the liposomes of certain intravenous fat emulsions associated with embolic effects in acutely ill patients, chylomicrons and very low density lipoproteins (VLDL) show calcium-dependent agglutination by C-reactive protein (CRP). It is suggested that non-traumatic fat embolism may be caused by agglutination of chylomicrons and VLDL by high levels of plasma CRP. This mechanism may also cause acute pancreatitis in patients with types I, IV, and V hyperlipidaemia, and avascular necrosis of bone in patients with corticosteroid-induced hyperlipidaemia.
与急性病患者的栓塞效应相关的某些静脉脂肪乳剂的脂质体一样，乳糜微粒和极低密度脂蛋白（VLDL）显示出C反应蛋白（CRP）依赖性的凝集。有人提出，非创伤性脂肪栓塞可能是由高水平血浆CRP导致的乳糜微粒和VLDL凝集引起的。这种机制也可能导致I型、IV型和V型高脂血症患者发生急性胰腺炎，以及皮质类固醇诱导的高脂血症患者发生骨缺血性坏死。
