Correction of stopping power and LET quenching for radiophotoluminescent glass dosimetry in a therapeutic proton beam.

To measure the absorbed dose to water D in proton beams using a radiophotoluminescent glass dosimeter (RGD), a method with the correction for the change of the mass stopping power ratio (SPR) and the linear energy transfer (LET) dependence of radiophotoluminescent efficiency [Formula: see text] is proposed. The calibration coefficient in terms of D for RGDs (GD-302M, Asahi Techno Glass) was obtained using a Co γ-ray. The SPR of water to the RGD was calculated by Monte Carlo simulation, and [Formula: see text] was investigated experimentally using a 70 MeV proton beam. For clinical usage, the residual range R was used as a quality index to determine the correction factor for the beam quality [Formula: see text] and the LET quenching effect of the RGD [Formula: see text]. The proposed method was evaluated by measuring D at different depths in a 200 MeV proton beam. For both non-modulated and modulated proton beams, [Formula: see text] decreases rapidly where R is less than 4 cm. The difference in [Formula: see text] between a non-modulated and a modulated proton beam is less than 0.5% for the R range from 0 cm to 22 cm. [Formula: see text] decreases rapidly at a LET range from 1 to 2 keV µm. In the evaluation experiments, D using RGDs, [Formula: see text] showed good agreement with that obtained using an ionization chamber and the relative difference was within 3% where R was larger than 1 cm. The uncertainty budget for [Formula: see text] in a proton beam was estimated to investigate the potential of RGD postal dosimetry in proton therapy. These results demonstrate the feasibility of RGD dosimetry in a therapeutic proton beam and the general versatility of the proposed method. In conclusion, the proposed methodology for RGDs in proton dosimetry is applicable where R   >  1 cm and the RGD is feasible as a postal audit dosimeter for proton therapy.