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用于质子治疗剂量学的新型掺镥硅基光纤材料。

Novel Gd-doped silica-based optical fiber material for dosimetry in proton therapy.

机构信息

TRIUMF, 4004 Wesbrook Mall, Vancouver, Canada.

Univ-Lyon, Laboratoire H. Curien, F-42000, Saint-Etienne, France.

出版信息

Sci Rep. 2019 Nov 8;9(1):16376. doi: 10.1038/s41598-019-52608-5.

Abstract

Optical fibers hold promise for accurate dosimetry in small field proton therapy due to their superior spatial resolution and the lack of significant Cerenkov contamination in proton beams. One known drawback for most scintillation detectors is signal quenching in areas of high linear energy transfer, as is the case in the Bragg peak region of a proton beam. In this study, we investigated the potential of innovative optical fiber bulk materials using the sol-gel technique for dosimetry in proton therapy. This type of glass is made of amorphous silica (SiO[Formula: see text]) and is doped with Gd[Formula: see text] ions and possesses very interesting light emission properties with a luminescence band around 314 nm when exposed to protons. The fibers were manufactured at the University of Lille and tested at the TRIUMF Proton Therapy facility with 8.2-62.9 MeV protons and 2-6 nA of extracted beam current. Dose-rate dependence and quenching were measured and compared to other silica-based fibers also made by sol-gel techniques and doped with Ce[Formula: see text] and Cu[Formula: see text]. The three fibers present strong luminescence in the UV (Gd) or visible (Cu,Ce) under irradiation, with the emission intensities related directly to the proton flux. In addition, the 0.5 mm diameter Gd[Formula: see text]-doped fiber shows superior resolution of the Bragg peak, indicating significantly reduced quenching in comparison to the Ce[Formula: see text] and Cu[Formula: see text] fibers with a Birks' constant, k[Formula: see text], of (0.0162 [Formula: see text] 0.0003) cm/MeV in comparison to (0.0333 [Formula: see text] 0.0006) cm/MeV and (0.0352 [Formula: see text] 0.0003) cm/MeV, respectively. To our knowledge, this is the first report of such an interesting k[Formula: see text] for a silica-based optical fiber material, showing clearly that this fiber presents lower quenching than common plastic scintillators. This result demonstrates the high potential of this inorganic fiber material for proton therapy dosimetry.

摘要

光纤由于其优越的空间分辨率和质子束中无明显切伦科夫辐射污染,因此有望在小野质子治疗中实现精确的剂量测量。对于大多数闪烁探测器来说,一个已知的缺点是在高线性转移能区的信号淬灭,就像质子束的布拉格峰区一样。在这项研究中,我们使用溶胶-凝胶技术研究了创新的光纤块状材料在质子治疗剂量测量中的潜力。这种玻璃由非晶态二氧化硅(SiO[公式:见文本])组成,并掺杂 Gd[公式:见文本]离子,具有非常有趣的发光特性,当暴露于质子时,其发光带在 314nm 左右。光纤是在里尔大学制造的,并在 TRIUMF 质子治疗设施中用 8.2-62.9MeV 的质子和 2-6nA 的提取束流进行了测试。测量了剂量率依赖性和猝灭,并与其他也通过溶胶-凝胶技术制造的、掺杂 Ce[公式:见文本]和 Cu[公式:见文本]的二氧化硅基光纤进行了比较。三种光纤在辐照下在 UV(Gd)或可见光(Cu,Ce)中均具有强烈的发光,其发射强度与质子通量直接相关。此外,直径为 0.5mm 的 Gd[公式:见文本]掺杂光纤显示出布拉格峰的分辨率更高,与 Ce[公式:见文本]和 Cu[公式:见文本]光纤相比,猝灭明显减少,其 Birks 常数 k[公式:见文本]为(0.0162 [公式:见文本] 0.0003)cm/MeV,而分别为(0.0333 [公式:见文本] 0.0006)cm/MeV 和(0.0352 [公式:见文本] 0.0003)cm/MeV。据我们所知,这是首次报道这种有趣的 k[公式:见文本]对于基于二氧化硅的光纤材料来说,这清楚地表明这种光纤的猝灭比普通塑料闪烁体低。这一结果表明,这种无机光纤材料在质子治疗剂量测量中具有很高的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70ee/6841944/23b7c8ca48c0/41598_2019_52608_Fig1_HTML.jpg

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