Nisoli E, Grilli M, Memo M, Missale C, Spano P F
Institute of Pharmacology and Experimental Therapeutics, School of Medicine, University of Brescia, Italy.
Neurosci Lett. 1988 May 3;87(3):247-52. doi: 10.1016/0304-3940(88)90456-9.
The mesolimbocortical dopaminergic system innervates several brain regions including the frontal cortex. The aim of our work was both to identify and to pharmacologically characterize the dopamine receptors located in this brain area. We found that different selective agonists for D1 receptors were able to increase adenylate cyclase activity, and these effects were antagonized by haloperidol and SCH 23390. Moreover different agonists for D2 receptors inhibited the cyclic AMP generating system, and these effects were prevented by (-)-sulpiride. According to the paradigm that D1 receptors are linked with adenylate cyclase in a stimulatory way, while D2 receptors are linked with the same enzyme in an inhibitory way, our results indicate the presence of both D1 and D2 receptors in rat frontal cortex.
中脑边缘皮质多巴胺能系统支配包括额叶皮质在内的多个脑区。我们工作的目的是识别并从药理学角度表征位于该脑区的多巴胺受体。我们发现，不同的D1受体选择性激动剂能够增加腺苷酸环化酶活性，且这些作用可被氟哌啶醇和SCH 23390拮抗。此外，不同的D2受体激动剂抑制环磷酸腺苷生成系统，且这些作用可被（-）-舒必利阻断。根据D1受体以刺激方式与腺苷酸环化酶相连，而D2受体以抑制方式与同一酶相连的模式，我们的结果表明大鼠额叶皮质中同时存在D1和D2受体。
