通过金属卡宾自由基途径的分子内直接 C-H 芳基化反应：平面手性二茂铁的立体专一性方法。
Intramolecular Direct C-H Arylation via a Metallocenic Radical Pathway: Stereospecific Approach to Planar-Chiral Ferrocenes.
机构信息
State Key Laboratory and Institute Elementoorganic Chemistry, College of Chemistry, Nankai University , Tianjin 300071, China.
出版信息
Org Lett. 2017 Oct 20;19(20):5709-5712. doi: 10.1021/acs.orglett.7b02995. Epub 2017 Oct 5.
PMID:28981297
Abstract
Transition metal-free synthesis of planar-chiral 1,2-fused ferrocenes via intramolecular direct C-H bond arylation was achieved. The C-H arylation reactions promoted by a catalytic amount of 1,10-phenanthroline highlighted a unique planar-chiral metallocenic radical intermediate, generated from iodoferrocenes via a single-electron transfer process.
摘要
通过分子内直接 C-H 键芳基化反应实现了无过渡金属的平面手性 1,2-二茂铁的合成。通过催化量的 1,10-菲咯啉促进的 C-H 芳基化反应突出了一种独特的平面手性金属自由基中间体，该中间体是通过单电子转移过程从碘代二茂铁生成的。
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