a Department of Ophthalmology , Chungnam National University College of Medicine , Daejeon , Republic of Korea.
b Department of Ophthalmology , Kosin University College of Medicine , Busan , Republic of Korea.
Ocul Immunol Inflamm. 2019;27(1):155-161. doi: 10.1080/09273948.2017.1353103. Epub 2017 Oct 5.
To evaluate the effectiveness of prophylactic systemic moxifloxacin in a rabbit model of Streptococcus viridans (S. viridans) endophthalmitis.
Animals (n=60) were divided into three groups. Intravenous moxifloxacin, vancomycin, normal saline was administered to 20 animals in each group and two hours later, 10 colony-forming units (CFU) of S. salivarius were intravitreally injected into the left eye. Intravenous antibiotics injection was repeated on days 1, 2, and 3 after inoculation. The clinical features, bacterial culture from vitreous aspirates of 10 eyes from each group were evaluated on days 1, 3, 5, and 7. On day 7, eyes for clinical feature examination were enucleated for histopathologic examination.
Clinical scores and logCFU/ml values were lower in moxifloxacin group on all examination days. Histopathologic examination showed less inflammation and relatively well-preserved retina in the moxifloxacin group.
Systemic moxifloxacin may have a prophyactic effect for S. viridans endophthalmitis after intraocular procedure.
评估预防性全身莫西沙星在兔草绿色链球菌（S. viridans）眼内炎模型中的疗效。
将 60 只动物分为三组。每组 20 只动物分别静脉注射莫西沙星、万古霉素和生理盐水，2 小时后，将 10 个 CFU 的 S. salivarius 经玻璃体内注射入左眼。接种后第 1、2、3 天重复静脉注射抗生素。在第 1、3、5 和 7 天，评估每组 10 只眼的玻璃体抽吸物的临床特征和细菌培养。第 7 天，对进行临床特征检查的眼进行眼球摘除，进行组织病理学检查。
在所有检查日，莫西沙星组的临床评分和 logCFU/ml 值均较低。组织病理学检查显示莫西沙星组炎症较轻，视网膜相对保存较好。
在眼内手术后，全身应用莫西沙星可能对草绿色链球菌眼内炎具有预防作用。
