Arf-GAP与蛋白质支架Cat1/Git1作为癌症进展的多面调节因子。
The Arf-GAP and protein scaffold Cat1/Git1 as a multifaceted regulator of cancer progression.
作者信息
Yoo Sungsoo M, Cerione Richard A, Antonyak Marc A
机构信息
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Department of Molecular Medicine, Cornell University, Ithaca, NY, USA.
出版信息
Small GTPases. 2020 Mar;11(2):77-85. doi: 10.1080/21541248.2017.1362496. Epub 2017 Dec 31.
Cool-associated tyrosine phosphorylated protein 1 (Cat1), also referred to as GPCR-kinase interacting protein 1 (Git1), is a ubiquitously expressed, multi-domain protein that is best known for regulating cell shape and migration. Cat1/Git1 functions as a GTPase activating protein (GAP) that inactivates certain members of the ADP-ribosylation factor (Arf) family of small GTPases. It is also a scaffold that brings together several signaling proteins at specific locations within the cell, ensuring their efficient activation. Here we will discuss what is known regarding the classical role of Cat1/Git1 in the regulation of cell morphology and migration, as well as highlight some more recent findings that suggest this interesting signaling/scaffolding protein may also contribute in unexpected ways to oncogenic transformation.
冷相关酪氨酸磷酸化蛋白1（Cat1），也被称为G蛋白偶联受体激酶相互作用蛋白1（Git1），是一种广泛表达的多结构域蛋白，以调节细胞形态和迁移而闻名。Cat1/Git1作为一种GTP酶激活蛋白（GAP），可使小GTP酶的ADP核糖基化因子（Arf）家族的某些成员失活。它也是一种支架蛋白，能在细胞内的特定位置聚集多种信号蛋白，确保它们的有效激活。在这里，我们将讨论关于Cat1/Git1在调节细胞形态和迁移中的经典作用的已知信息，并强调一些最新发现，这些发现表明这种有趣的信号/支架蛋白可能也以意想不到的方式促进致癌转化。
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