Porta S, Hofmann H M, Ertl U, Rinner I, Puerstner P, Weiss P A, Felsner P, Korsatko W
Institut für funktionelle Pathologie, Universität Graz, Austria.
Acta Endocrinol (Copenh). 1988 Feb;117(2):166-72. doi: 10.1530/acta.0.1170166.
A comparison of the action of adrenaline infusion and a combined adrenaline + alpha blocker (phentolamine, Regitine) infusion on blood glucose (BG), plasma immunoreactive insulin (IRI), BG/IRI ratio, C-peptide, and plasma cortisol levels was made in healthy young human subjects. The purpose of the experiment was to check, whether alpha block could abolish adrenaline-induced enhancement of blood glucose levels. The results show that during enhanced adrenaline levels, the use of regitine could indeed normalize blood glucose levels, not so much by increasing the IRI secretion, but by diminishing adrenaline-induced liver glycogenolysis via alpha receptors. This could be a model to prevent stress (adrenaline) induced metabolic deviations in diabetics, especially before and during predictable stress situations, e.g. examinations or surgery.
在健康年轻受试者中，比较了静脉输注肾上腺素以及联合输注肾上腺素与α受体阻滞剂（酚妥拉明，立其丁）对血糖（BG）、血浆免疫反应性胰岛素（IRI）、BG/IRI比值、C肽和血浆皮质醇水平的影响。本实验的目的是检验α受体阻滞是否能够消除肾上腺素引起的血糖水平升高。结果显示，在肾上腺素水平升高期间，使用立其丁确实能够使血糖水平恢复正常，这并非主要通过增加IRI分泌，而是通过α受体减少肾上腺素诱导的肝糖原分解来实现。这可能是一种预防糖尿病患者应激（肾上腺素）诱导的代谢偏差的模式，尤其是在可预测的应激情况（如考试或手术）之前和期间。
