Corson S A, Corson E O
Department of Psychiatry, Ohio State University, Columbus.
Act Nerv Super (Praha). 1988 Jan;30(1):22-39.
Experiments on naturally occurring hyperkinetic and violent dogs and cats demonstrated the usefulness of low dosages of amphetamine (0,2-1,0 mg/kg per os) in inhibiting these nonadaptive forms of behavior, permitting the development of discriminated Pavlovian and operant conditional responses. When amphetamine therapy was combined systematically with conditioning experiments and psychosocial therapy, for long enough periods of time (many weeks), the beneficial effects of this drug persisted in the nodrug state, i.e. the learning was not state-dependent. Amphetamine also ameliorated significantly conditional emotional visceral responses in dogs with low adaptation to psychologically stressful situations. The same low dosage of amphetamine which improved the behavior and learning of hyperkinetic and violent dogs disrupted the behavior and produced disorientation in normal dogs with previously stable conditional responses.
对自然出现的运动亢进和暴力的犬猫进行的实验表明，低剂量的苯丙胺（0.2 - 1.0毫克/千克口服）在抑制这些非适应性行为形式方面是有用的，能够使辨别性巴甫洛夫条件反射和操作性条件反应得以发展。当苯丙胺治疗与条件反射实验及心理社会治疗系统地结合足够长的时间（数周）时，这种药物的有益效果在停药状态下仍然持续存在，即学习不是状态依赖的。苯丙胺还显著改善了对心理应激情况适应能力低的犬的条件性情绪内脏反应。同样低剂量的苯丙胺改善了运动亢进和暴力犬的行为和学习能力，却扰乱了先前条件反应稳定的正常犬的行为并使其产生定向障碍。
