Merashli Mira, Noureldine Mohammad Hassan A, Tfayli Yehia, Jawad Ali, Uthman Imad
Department of Internal Medicine, Division of Rheumatology, American University of Beirut, Beirut, Lebanon.
Department of Neurosurgery, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon.
Endocr Metab Immune Disord Drug Targets. 2018 Feb 13;18(2):148-154. doi: 10.2174/1871530317666171003155517.
Familial Mediterranean Fever (FMF) is one of the most common hereditary auto-inflammatory diseases especially among Arabs, Armenians, Jews, and Turks characterized by recurrent attacks of fever, abdominal pain and arthritis.Whether the prevalence of ankylosing spondylitis (AS) is increased in FMF patients is a matter of debate. This review will summarize all the literature data relevant to this topic.
We searched all the articles through PubMed and Embase databases from 1963 until 2017 addressing the relationship between AS and FMF patients.
The prevalence of AS among FMF patients is highly variable. However, a significant relationship was found to exist between MEFV gene mutations and AS. Most patients with coexistent MEFV gene mutations and AS were human leucocyte antigen B27 (HLA-B27) negative. The effect of these mutations on AS severity and prognosis was not significant.
Large based population studies are needed to further assess the existence of MEFV gene mutations among AS patients and their effect on the clinical course of the disease in addition to assessment of AS prevalence in patients with FMF.
家族性地中海热（FMF）是最常见的遗传性自身炎症性疾病之一，在阿拉伯人、亚美尼亚人、犹太人及土耳其人中尤为常见，其特征为反复发热、腹痛和关节炎发作。FMF患者中强直性脊柱炎（AS）的患病率是否增加存在争议。本综述将总结与该主题相关的所有文献数据。
我们通过PubMed和Embase数据库检索了1963年至2017年期间所有探讨AS与FMF患者之间关系的文章。
FMF患者中AS的患病率差异很大。然而，发现MEFV基因突变与AS之间存在显著关系。大多数同时存在MEFV基因突变和AS的患者人类白细胞抗原B27（HLA - B27）呈阴性。这些突变对AS严重程度和预后的影响不显著。
除了评估FMF患者中AS的患病率外，还需要开展大规模人群研究，以进一步评估AS患者中MEFV基因突变的存在情况及其对疾病临床进程的影响。
