β2-肾上腺素能受体拮抗剂ICI 118,551对已知对β1-肾上腺素能受体拮抗剂有反应的高血压患者血压的影响。
Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists.
作者信息
Robb O J, Webster J, Petrie J C, Harry J D, Young J
机构信息
Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill.
出版信息
Br J Clin Pharmacol. 1988 Apr;25(4):433-8. doi: 10.1111/j.1365-2125.1988.tb03326.x.
Abstract
- The selective beta 2-adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1-adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2-selective antagonism does not play a role in the hypotensive action of beta-adrenoceptor antagonists.
摘要
- 选择性β2肾上腺素能受体拮抗剂ICI 118,551，每日口服3次，每次50毫克，对已知对阿替洛尔或普萘洛尔治疗有反应的高血压患者并无降压作用。2. 这种给药方案导致仰卧心率略有下降，这可能代表ICI 118,551对β1肾上腺素能受体有部分拮抗作用。3. 结果表明，β2选择性拮抗作用在β肾上腺素能受体拮抗剂的降压作用中不起作用。
相似文献
1
Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists.β2-肾上腺素能受体拮抗剂ICI 118,551对已知对β1-肾上腺素能受体拮抗剂有反应的高血压患者血压的影响。
Br J Clin Pharmacol. 1988 Apr;25(4):433-8. doi: 10.1111/j.1365-2125.1988.tb03326.x.
2
Antihypertensive mechanism of beta-adrenoceptor antagonism--the role of beta 2-blockade.β-肾上腺素能受体拮抗的降压机制——β₂受体阻断的作用
J Hypertens Suppl. 1983 Dec;1(2):112-5.
3
The comparative effects of ICI 118551 and propranolol on essential tremor.ICI 118551与普萘洛尔对特发性震颤的比较效果。
Br J Clin Pharmacol. 1987 Dec;24(6):729-34. doi: 10.1111/j.1365-2125.1987.tb03238.x.
4
Compound ICI 118,551, a beta 2-adrenoceptor antagonist, lowers blood pressure.化合物ICI 118,551，一种β2肾上腺素能受体拮抗剂，可降低血压。
J Hypertens Suppl. 1985 Dec;3(3):S247-9.
5
Initial clinical experience with ICI 141,292 (Visacor), a new selective beta 1-adrenoceptor blocker with ISA--a multicentre trial in 59 patients.ICI 141,292（Visacor）的初步临床经验，一种具有内源性拟交感活性的新型选择性β1肾上腺素受体阻滞剂——一项针对59例患者的多中心试验。
Br J Clin Pharmacol. 1984 Dec;18(6):831-6. doi: 10.1111/j.1365-2125.1984.tb02552.x.
6
Effects of ICI 141,292 on exercise tachycardia and isoprenaline-induced beta-adrenoceptor responses in man.ICI 141,292对人体运动性心动过速及异丙肾上腺素诱导的β-肾上腺素能受体反应的影响。
Br J Clin Pharmacol. 1986 Mar;21(3):249-58. doi: 10.1111/j.1365-2125.1986.tb05187.x.
7
Effects of selective beta 2-adrenoceptor blockade on serum potassium and exercise performance in normal men.选择性β2-肾上腺素能受体阻断对正常男性血清钾及运动能力的影响。
Br J Clin Pharmacol. 1991 Aug;32(2):201-7. doi: 10.1111/j.1365-2125.1991.tb03882.x.
8
Does beta 1-selective agonistic activity interfere with the antihypertensive efficacy of beta 1-selective blocking agents?β1 选择性激动活性是否会干扰β1 选择性阻断剂的降压疗效？
J Hypertens Suppl. 1985 Dec;3(3):S243-5.
9
Involvement of beta 2-adrenoceptor-mediated mechanisms in the cardiovascular responses to alpha 1- and alpha 2-adrenoceptor antagonism in conscious, unrestrained, Long Evans and Brattleboro rats.β2-肾上腺素能受体介导的机制在清醒、自由活动的长 Evans 大鼠和布拉特洛维大鼠对α1-和α2-肾上腺素能受体拮抗的心血管反应中的作用。
Br J Pharmacol. 1988 Jan;93(1):9-22. doi: 10.1111/j.1476-5381.1988.tb11400.x.
10
The effect of epanolol on intra-arterial ambulatory blood pressure and baroreceptor heart rate reflex in essential hypertension.依帕诺洛尔对原发性高血压患者动脉内动态血压及压力感受器心率反射的影响
Clin Exp Pharmacol Physiol. 1988 Apr;15(4):327-31. doi: 10.1111/j.1440-1681.1988.tb01082.x.
引用本文的文献
1
β1-Adrenoreceptor Polymorphisms and Blood Pressure: 49S Variant Increases Plasma Renin But Not Blood Pressure in Hypertensive Patients.β1-肾上腺素能受体多态性与血压：49S 变异型增加高血压患者的血浆肾素但不增加血压。
Am J Hypertens. 2019 Apr 22;32(5):447-451. doi: 10.1093/ajh/hpz019.
2
Selection of β-Blocker in Patients With Cirrhosis and Acute Myocardial Infarction: A 13-Year Nationwide Population-Based Study in Asia.肝硬化合并急性心肌梗死患者β受体阻滞剂的选择：亚洲一项为期 13 年的全国性基于人群的研究。
J Am Heart Assoc. 2018 Oct 2;7(19):e008982. doi: 10.1161/JAHA.118.008982.
3
Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels.人类体内非肾上腺生成肾上腺素的酶。特性、分布、调节及其与肾上腺素水平的关系。
J Clin Invest. 1995 Jun;95(6):2896-902. doi: 10.1172/JCI117996.
本文引用的文献
1
Withdrawal of long-term therapy with atenolol in hypertensive patients.高血压患者停用阿替洛尔长期治疗
Br J Clin Pharmacol. 1981 Aug;12(2):211-4. doi: 10.1111/j.1365-2125.1981.tb01202.x.
2
Hypokalemia from beta2-receptor stimulation by circulating epinephrine.循环肾上腺素通过β2受体刺激导致低钾血症。
N Engl J Med. 1983 Dec 8;309(23):1414-9. doi: 10.1056/NEJM198312083092303.
3
The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551).一种β2 选择性肾上腺素能受体拮抗剂（ICI 118,551）的药理学
J Cardiovasc Pharmacol. 1983 May-Jun;5(3):430-7. doi: 10.1097/00005344-198305000-00013.
4
Antihypertensive mechanism of beta-adrenoceptor antagonism--the role of beta 2-blockade.β-肾上腺素能受体拮抗的降压机制——β₂受体阻断的作用
J Hypertens Suppl. 1983 Dec;1(2):112-5.
5
Effect of ICI 118551 on bronchial beta-adrenoceptor function and exercise heart rate in normal man.ICI 118551对正常男性支气管β-肾上腺素能受体功能及运动心率的影响。
Br J Clin Pharmacol. 1983 Dec;16(6):587-90. doi: 10.1111/j.1365-2125.1983.tb02226.x.
6
Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding.人右心房中β1和β2肾上腺素能受体的共存。通过（±）-[125I]碘氰吲哚洛尔结合进行直接鉴定。
Circ Res. 1983 Dec;53(6):752-8. doi: 10.1161/01.res.53.6.752.
7
How beta2-selective is the adrenoceptor antagonist drug, IPS 339?肾上腺素能受体拮抗剂药物IPS 339对β2的选择性如何？
J Pharm Pharmacol. 1981 Apr;33(4):223-5. doi: 10.1111/j.2042-7158.1981.tb13762.x.
8
Confidence intervals rather than P values: estimation rather than hypothesis testing.置信区间而非P值：估计而非假设检验。
Br Med J (Clin Res Ed). 1986 Mar 15;292(6522):746-50. doi: 10.1136/bmj.292.6522.746.
9
Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on exercise tachycardia and isoprenaline-induced beta-adrenoceptor responses in man.β2肾上腺素能受体拮抗剂ICI 118,551对人体运动性心动过速及异丙肾上腺素诱导的β肾上腺素能受体反应的影响。
Br J Clin Pharmacol. 1985 May;19(5):619-30. doi: 10.1111/j.1365-2125.1985.tb02689.x.
Zotero 插件