β2-肾上腺素能受体拮抗剂ICI 118,551对已知对β1-肾上腺素能受体拮抗剂有反应的高血压患者血压的影响。
Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists.
作者信息
Robb O J, Webster J, Petrie J C, Harry J D, Young J
机构信息
Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill.
出版信息
Br J Clin Pharmacol. 1988 Apr;25(4):433-8. doi: 10.1111/j.1365-2125.1988.tb03326.x.
Abstract
- The selective beta 2-adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1-adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2-selective antagonism does not play a role in the hypotensive action of beta-adrenoceptor antagonists.
摘要
- 选择性β2肾上腺素能受体拮抗剂ICI 118,551，每日口服3次，每次50毫克，对已知对阿替洛尔或普萘洛尔治疗有反应的高血压患者并无降压作用。2. 这种给药方案导致仰卧心率略有下降，这可能代表ICI 118,551对β1肾上腺素能受体有部分拮抗作用。3. 结果表明，β2选择性拮抗作用在β肾上腺素能受体拮抗剂的降压作用中不起作用。
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