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A multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/- nab-paclitaxel in elderly pancreatic cancer patients (GrantPax).多中心 4 期老年综合评估指导试验,旨在评估吉西他滨 +/- 白蛋白紫杉醇在老年胰腺癌患者中的疗效(GrantPax)。
BMC Cancer. 2018 Jul 18;18(1):747. doi: 10.1186/s12885-018-4665-2.
2
HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma.Halo202:PEGPH20 联合 Nab-紫杉醇/吉西他滨与 Nab-紫杉醇/吉西他滨治疗未经治疗的转移性胰腺导管腺癌患者的随机 II 期研究。
J Clin Oncol. 2018 Feb 1;36(4):359-366. doi: 10.1200/JCO.2017.74.9564. Epub 2017 Dec 12.
3
Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of Necuparanib Combined with Nab-Paclitaxel and Gemcitabine in Patients with Metastatic Pancreatic Cancer: Phase I Results.尼妥珠单抗联合白蛋白紫杉醇和吉西他滨治疗转移性胰腺癌患者的安全性、药代动力学、药效学和抗肿瘤活性:I 期研究结果。
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A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial.随机、双盲、Ⅱ期试验:吉西他滨联合nab-紫杉醇加阿帕瑟森或安慰剂治疗转移性胰腺癌患者:RAINIER 试验。
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Comparison of efficacy and toxicity of FOLFIRINOX and gemcitabine with nab-paclitaxel in unresectable pancreatic cancer.FOLFIRINOX方案与吉西他滨联合纳米白蛋白紫杉醇治疗不可切除胰腺癌的疗效和毒性比较
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胰腺癌临床试验:漫漫征途。

Clinical Trials in Pancreatic Cancer: A Long Slog.

机构信息

Division of Hematology and Oncology, Department of Medicine, Columbia University Medical Center, New York, New York, USA

Division of Hematology and Oncology, Department of Medicine, Columbia University Medical Center, New York, New York, USA.

出版信息

Oncologist. 2017 Dec;22(12):1424-1426. doi: 10.1634/theoncologist.2017-0453. Epub 2017 Oct 5.

DOI:10.1634/theoncologist.2017-0453
PMID:28982802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5728038/
Abstract

Many investigators have turned their efforts toward improving the gemcitabine/nab‐paclitaxel combination by the addition of a third agent. This commentary highlights efforts to date, including the Clinical Trial Results by Ko et al.: A Randomized Double‐Blinded Phase II Trial of Gemcitabine and Nab‐Paclitaxel Plus Apatorsen or Placebo in Patients with Metastati Pancreatic Cancer: The RAINIER Trial.

摘要

许多研究人员致力于通过添加第三种药物来改进吉西他滨/纳布紫杉醇联合用药。这篇评论重点介绍了迄今为止的努力,包括 Ko 等人的临床试验结果:吉西他滨和纳布紫杉醇加 Apatorsen 或安慰剂治疗转移性胰腺癌患者的随机双盲 II 期试验:RAINIER 试验。