经动脉化疗栓塞术治疗的肝细胞癌患者肝脏实质血容量及动态容积灌注CT测量

Parenchymal Liver Blood Volume and Dynamic Volume Perfusion CT Measurements of Hepatocellular Carcinoma in Patients Undergoing Transarterial Chemoembolization.

作者信息

Rathmann Nils, Kara Kerim, Budjan Johannes, Henzler Thomas, Smakic Arman, Schoenberg Stefan O, Diehl Steffen J

机构信息

Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

Fraunhofer Project Group for Automation in Medicine and Biotechnology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

出版信息

Anticancer Res. 2017 Oct;37(10):5681-5685. doi: 10.21873/anticanres.12004.

DOI:10.21873/anticanres.12004

PMID:28982886

Abstract

AIM

Prospective comparison of cone beam C-Arm CT based parenchymal liver blood volume (PLBV) and dynamic volume perfusion CT (dVPCT) measurements in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolisation (TACE) with drug-eluting beads (DEB).

PATIENTS AND METHODS

In 16 patients, changes of PLBV and dVPCT measurements [arterial liver parenchyma (ALP); temporal maximum intensity projection (MIP); hepatic perfusion index (HPI); portal venous parenchyma] were correlated to one another and to the modified Response Evaluation Criteria in Solid Tumors (mRECIST).

RESULTS

After TACE, the following parameters showed a statistically significant change (p<0.05) in mean value: PLBV: -4.85 ml/100 ml, ALP: -4.14 ml/100 ml/min, MIP: -0.23 Houndsfield units, HPI: -5.39%, and mRECIST: -20.53 mm. Pre-to-post TACE differences in PLBV showed only weak to very weak correlation to dVPCT parameters (r<0.24).

CONCLUSION

Although PLBV and dVPCT parameters showed only a weak to very weak correlation, both methods validly assessed changes in arterial tumor vascularity after DEB TACE.

摘要

目的

对接受载药微球（DEB）经动脉化疗栓塞术（TACE）的肝细胞癌（HCC）患者，基于锥形束C型臂CT测量的肝实质血容量（PLBV）和动态容积灌注CT（dVPCT）测量结果进行前瞻性比较。

患者与方法

对16例患者，PLBV和dVPCT测量结果的变化[肝动脉实质（ALP）；时间最大密度投影（MIP）；肝灌注指数（HPI）；门静脉实质]相互关联，并与实体瘤改良疗效评价标准（mRECIST）相关联。

结果

TACE术后，以下参数的平均值出现统计学显著变化（p<0.05）：PLBV：-4.85 ml/100 ml，ALP：-4.14 ml/100 ml/min，MIP：-0.23亨氏单位，HPI：-5.39%，mRECIST：-20.53 mm。TACE术前至术后PLBV的差异与dVPCT参数仅显示弱至非常弱的相关性（r<0.24）。