位于11号染色体上的第三个人类CALC（假）基因。

A third human CALC (pseudo)gene on chromosome 11.

作者信息

Höppener J W, Steenbergh P H, Zandberg J, Adema G J, Geurts van Kessel A H, Lips C J, Jansz H S

机构信息

Institute of Molecular Biology, State University of Utrecht, The Netherlands.

出版信息

FEBS Lett. 1988 Jun 6;233(1):57-63. doi: 10.1016/0014-5793(88)81355-3.

DOI:10.1016/0014-5793(88)81355-3

PMID:2898385

Abstract

A genomic locus in man (CALC-III) containing nucleotide sequences highly homologous to both exon 2 and exon 3 of the CALC-I and -II genes, is described in this paper. The CALC-I gene produces calcitonin (CT) (encoded by exon 4) or calcitonin gene-related peptide (CGRP) (encoded by exon 5) in a tissue-specific fashion. The CALC-II gene produces a second human CGRP, but probably not a second CT. The CALC-III gene does not seem to encode a CT- or CGRP-related polypeptide hormone and is probably a pseudogene. Like the other two CALC genes, the CALC-III gene is located on human chromosome 11.

摘要

本文描述了人类基因组中的一个位点（CALC-III），其核苷酸序列与CALC-I和-II基因的外显子2和外显子3高度同源。CALC-I基因以组织特异性方式产生降钙素（CT）（由外显子4编码）或降钙素基因相关肽（CGRP）（由外显子5编码）。CALC-II基因产生第二种人类CGRP，但可能不产生第二种CT。CALC-III基因似乎不编码与CT或CGRP相关的多肽激素，可能是一个假基因。与其他两个CALC基因一样，CALC-III基因位于人类11号染色体上。