Notch1 在结直肠癌患者中的表达谱及临床病理意义：一项荟萃分析。
The expression profile and clinicopathological significance of Notch1 in patients with colorectal cancer: a meta-analysis.
机构信息
Department of Pathology & Key Laboratory of Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Department of Pathology, the First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China.
出版信息
Future Oncol. 2017 Oct;13(23):2103-2118. doi: 10.2217/fon-2017-0178. Epub 2017 Oct 6.
AIM
This meta-analysis was conducted to evaluate the clinicopathological significance of Notch1 expression in patients with colorectal cancer (CRC).
METHODS
Available articles were searched from diverse databases, and the meta-analysis was done by using Stata 12.0 software.
RESULTS
Thirteen studies were included in this analysis (3401 samples). The Notch1 expression in CRC tissues was significantly higher than that in normal tissues statistically (OR: 15.46; 95% CI: 8.11-29.45; p = 0.003), and were associated with lymph node metastasis, tumor stage, depth of infiltration and histological differentiation.
DISCUSSION
There is a close relationship between higher Notch1 expression in CRC. Notch1 may be involved in tumor progression, invasion and metastasis with CRC.
CONCLUSION
Notch1 overexpression in CRC suggested aggressive biological behaviors and thus implying that Notch1 may be a useful biomarker in CRCs.
目的
本荟萃分析旨在评估 Notch1 表达在结直肠癌（CRC）患者中的临床病理意义。
方法
从多个数据库中检索到可用的文章，并使用 Stata 12.0 软件进行荟萃分析。
结果
该分析纳入了 13 项研究（3401 例样本）。CRC 组织中的 Notch1 表达明显高于正常组织（OR：15.46；95%CI：8.11-29.45；p=0.003），与淋巴结转移、肿瘤分期、浸润深度和组织学分化有关。
讨论
CRC 中 Notch1 表达较高存在密切关系。Notch1 可能参与 CRC 的肿瘤进展、侵袭和转移。
结论
CRC 中 Notch1 的过表达提示侵袭性生物学行为，因此提示 Notch1 可能是 CRC 中的一个有用的生物标志物。
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