肥胖儿童心血管疾病的危险因素

Risk Factors for Cardiovascular Disease in Obese Children.

作者信息

Chandrasekhar T, Suchitra M M, Pallavi M, L N Srinivasa Rao P V, Sachan Alok

机构信息

Departments of Biochemistry and *Endocrinology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India. Correspondence to: Dr MM Suchitra, Associate Professor, Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

出版信息

Indian Pediatr. 2017 Sep 15;54(9):752-755. doi: 10.1007/s13312-017-1169-0.

DOI:10.1007/s13312-017-1169-0

PMID:28984255

Abstract

OBJECTIVE

To study the prevalence of cardiovascular risk factors in pediatric obesity.

METHODS

50 obese children (age 5-17y) and 50 apparently healthy non-obese children (body mass index of over 95th percentile and between 5th to 95th percentiles, respectively) using Centre for Disease Control growth charts were included. Fasting blood sugar, lipid profile, insulin, homeostasis model assessment of insulin resistance, uric acid, fibrinogen, lipoprotein (a), homocysteine, malondialdehyde, ferric reducing ability of plasma and nitric oxide were measured.

RESULTS

Insulin, insulin resistance, triglycerides, uric acid, fibrinogen, malondialdehyde, ferric reducing ability of plasma and nitric oxide were significantly higher (P <0.001) in obese children. Body mass index showed significant positive correlation with insulin r=0.519, P<0.001; insulin resistance r =0.479, P<0.001; uric acid r= 0.289, P=0.005; fibrinogen r=0.461, P<0.001; and nitric oxide r=0.235, P=0.012.

CONCLUSION

Pediatric obesity is associated with dyslipidemia, oxidative stress, insulin resistance and endothelial dysfunction, which are cardiovascular risk factors and components of metabolic syndrome. These children must be targeted for lifestyle and dietary modification.

摘要

目的

研究儿童肥胖中心血管危险因素的患病率。

方法

纳入50名肥胖儿童（年龄5 - 17岁）和50名明显健康的非肥胖儿童（体重指数分别超过第95百分位数和处于第5至95百分位数之间），使用疾病控制中心生长图表。测量空腹血糖、血脂谱、胰岛素、胰岛素抵抗的稳态模型评估、尿酸、纤维蛋白原、脂蛋白(a)、同型半胱氨酸、丙二醛、血浆铁还原能力和一氧化氮。

结果

肥胖儿童的胰岛素、胰岛素抵抗、甘油三酯、尿酸、纤维蛋白原、丙二醛、血浆铁还原能力和一氧化氮显著更高（P <0.001）。体重指数与胰岛素呈显著正相关，r = 0.519，P <0.001；与胰岛素抵抗r = 0.479，P <0.001；与尿酸r = 0.289，P = 0.005；与纤维蛋白原r = 0.461，P <0.001；与一氧化氮r = 0.235，P = 0.012。