Liu Kwei-Lan, Tsai Wen-Chien, Lee Chih-Hung
Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Medicine (Baltimore). 2017 Oct;96(40):e8158. doi: 10.1097/MD.0000000000008158.
Sarcoidosis is a systemic granulomatous disorder of unknown etiology often involving skin. Studies on cutaneous sarcoidosis and comorbidities are limited. This study is aimed to describe the clinical features of cutaneous sarcoidosis diagnosed in our hospital and to determine the relationships between cutaneous sarcoidosis and comorbidities.This retrospective study evaluates patients with cutaneous sarcoidosis in a tertiary center in Taiwan from 1996 to 2015. The records of 38 patients with cutaneous sarcoidosis were reviewed for clinical characteristics and evaluated by analysis of variance. A 1:4 case-control analysis was conducted with 152 age- and sex-matched controls who underwent biopsy for other benign skin tumors.The male to female ratio was 1:4.4. The average age at diagnosis was 51.7 years. Female patients were on average 13.9 years older than male patients. The correlation of age with gender was statistically significant (P = .037). The most common cutaneous lesions were plaques (47.4%) and confined to the face (71.1%). Of the 38 patients, 26.3% had diabetes mellitus. Age over 40 (P = .014) and female (P = .014) were associated with facial involvement. In the case-control study, a higher percentage of patients with cutaneous sarcoidosis than of control subjects had diabetes mellitus (P = .001), hearing loss (P = .031) and eye diseases (P = .047).The present study demonstrates a striking female predominance and high proportions of facial involvement. Diabetes mellitus, hearing loss, and eye diseases may be associated with Taiwanese patients with cutaneous sarcoidosis.
结节病是一种病因不明的系统性肉芽肿性疾病，常累及皮肤。关于皮肤结节病及其合并症的研究有限。本研究旨在描述我院诊断的皮肤结节病的临床特征，并确定皮肤结节病与合并症之间的关系。这项回顾性研究评估了1996年至2015年台湾某三级中心的皮肤结节病患者。回顾了38例皮肤结节病患者的记录以了解其临床特征，并通过方差分析进行评估。对152名年龄和性别匹配的对照者进行了1:4病例对照分析，这些对照者因其他良性皮肤肿瘤接受了活检。男女比例为1:4.4。诊断时的平均年龄为51.7岁。女性患者平均比男性患者大13.9岁。年龄与性别的相关性具有统计学意义（P = 0.037）。最常见的皮肤损害是斑块（47.4%），且局限于面部（71.1%）。38例患者中，26.3%患有糖尿病。40岁以上（P = 0.014）和女性（P = 0.014）与面部受累有关。在病例对照研究中，皮肤结节病患者患糖尿病（P = 0.001）、听力损失（P = 0.031）和眼部疾病（P = 0.047）的比例高于对照者。本研究表明女性占主导地位且面部受累比例高。糖尿病、听力损失和眼部疾病可能与台湾皮肤结节病患者有关。
