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Sodium fluoride PET imaging as a quantitative pharmacodynamic biomarker for bone homeostasis during anti-DKK1 therapy for multiple myeloma.

作者信息

Wang Y, Yee A J, Sirard C, Landau S, Raje N, Mahmood U

机构信息

Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

Harvard Medical School, Boston, MA, USA.

出版信息

Blood Cancer J. 2017 Oct 6;7(10):e615. doi: 10.1038/bcj.2017.95.

DOI:10.1038/bcj.2017.95
PMID:28984867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5678221/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04d/5678221/f28dd0406699/bcj201795f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04d/5678221/f28dd0406699/bcj201795f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04d/5678221/f28dd0406699/bcj201795f1.jpg

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本文引用的文献

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A Phase IB multicentre dose-determination study of BHQ880 in combination with anti-myeloma therapy and zoledronic acid in patients with relapsed or refractory multiple myeloma and prior skeletal-related events.一项关于BHQ880联合抗骨髓瘤疗法及唑来膦酸用于复发或难治性多发性骨髓瘤且既往有骨相关事件患者的IB期多中心剂量确定研究。
Br J Haematol. 2014 Nov;167(3):366-75. doi: 10.1111/bjh.13056. Epub 2014 Aug 19.
2
Role of 18F-fluoride PET/CT in the assessment of multiple myeloma: initial experience.18F-氟代脱氧葡萄糖 PET/CT 在多发性骨髓瘤评估中的作用：初步经验。
Ann Nucl Med. 2013 Jan;27(1):78-83. doi: 10.1007/s12149-012-0647-7. Epub 2012 Aug 23.
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Int J Mol Sci. 2019 Aug 30;20(17):4242. doi: 10.3390/ijms20174242.
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Hybrid PET/MR Kernelised Expectation Maximisation Reconstruction for Improved Image-Derived Estimation of the Input Function from the Aorta of Rabbits.用于从兔主动脉改善图像衍生输入函数估计的混合 PET/MR 核化期望最大化重建。
Contrast Media Mol Imaging. 2019 Jan 16;2019:3438093. doi: 10.1155/2019/3438093. eCollection 2019.
The kinetics and reproducibility of 18F-sodium fluoride for oncology using current PET camera technology.
当前 PET 相机技术在肿瘤学中应用 18F-氟化钠的动力学和可重复性。
J Nucl Med. 2012 Aug;53(8):1175-84. doi: 10.2967/jnumed.111.100883. Epub 2012 Jun 22.
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The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions.不同受力条件下 Dickkopf-1 抗体对骺骨和种植体固定的影响。
Bone. 2011 May 1;48(5):988-96. doi: 10.1016/j.bone.2011.02.008. Epub 2011 Feb 15.
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Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1.统一临床试验报告的共识建议：国际骨髓瘤工作组共识小组报告 1.
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Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition.多发性骨髓瘤骨病：成骨细胞抑制的病理生理学
Blood. 2006 Dec 15;108(13):3992-6. doi: 10.1182/blood-2006-05-026112. Epub 2006 Aug 17.
10
Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.基于多次摄取数据对血脑转运常数的图形评估。
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