Pharmacology and Therapeutics, Biomedical Sciences, Dangan, NUI Galway, Galway, Ireland.
VIB Inflammation Research Center, Ghent, Belgium.
Cell Death Differ. 2017 Dec;24(12):1991-1998. doi: 10.1038/cdd.2017.149. Epub 2017 Oct 6.
In the last few years many new cell death modalities have been described. To classify different types of cell death, the term 'regulated cell death' was introduced to discriminate it from 'accidental cell death'. Regulated cell death involves the activation of genetically encoded molecular machinery that couples the presence of some signal to cell death. These forms of cell death, like apoptosis, necroptosis and pyroptosis have important physiological roles in development, tissue repair, and immunity. Accidental cell death occurs in response to physical or chemical insults and occurs independently of molecular signalling pathways. Ferroptosis, an emerging and recently (re)discovered type of regulated cell death occurs through Fe(II)-dependent lipid peroxidation when the reduction capacity of a cell is insufficient. Ferroptosis is coined after the requirement for free ferrous iron. Here, we will consider the extent to which ferroptosis is similar to other regulated cell deaths and explore emerging ideas about the physiological role of ferroptosis.
在过去的几年中，已经描述了许多新的细胞死亡方式。为了对不同类型的细胞死亡进行分类，引入了“程序性细胞死亡”一词，将其与“意外细胞死亡”区分开来。程序性细胞死亡涉及到激活基因编码的分子机制，将某些信号与细胞死亡联系起来。这些形式的细胞死亡，如细胞凋亡、坏死性凋亡和细胞焦亡，在发育、组织修复和免疫中具有重要的生理作用。意外细胞死亡是对物理或化学损伤的反应，独立于分子信号通路发生。铁死亡是一种新出现的、最近（重新）发现的程序性细胞死亡类型，当细胞的还原能力不足时，通过铁依赖性脂质过氧化发生。铁死亡这个词是由游离亚铁的需求衍生而来的。在这里，我们将考虑铁死亡与其他程序性细胞死亡的相似程度，并探讨铁死亡的生理作用的新观点。
