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可生物降解水凝胶间隔物注射对头颈部癌症放疗中保留对侧颌下腺的影响。

Effects of biodegradable hydrogel spacer injection on contralateral submandibular gland sparing in radiotherapy for head and neck cancers.

机构信息

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, USA.

Department of Radiology, Johns Hopkins School of Medicine, Baltimore, USA.

出版信息

Radiother Oncol. 2018 Jan;126(1):96-99. doi: 10.1016/j.radonc.2017.09.017. Epub 2017 Oct 3.

DOI:10.1016/j.radonc.2017.09.017
PMID:28985953
Abstract

Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.

摘要

口干症是头颈部放疗后最常见的晚期毒性反应。我们展示了一种将水凝胶间隔物注射到颌下腺前方的方法，使颌下腺向前移位。在接受调强放疗的口咽癌尸体模型中，这种方法可减少对移位的颌下腺的剂量，从而降低口干症的风险。

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