Takeda Shigeki
Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma, 376-8515, Japan.
Biophys Rev. 2018 Apr;10(2):141-144. doi: 10.1007/s12551-017-0326-y. Epub 2017 Oct 6.
Professor Fumio Arisaka is one of the famous leaders in bacteriophage research, especially in the areas of protein biophysics and structural biology. Autonomous phage morphogenesis is a self-assembly process controlled by subunit-subunit interaction. Under this principle, Fumio has studied T4 tail assembly and morphology. He has also contributed structural information about T4 phage through a combination of X-ray structural analysis and three-dimensional image reconstruction using cryo-electron microscopy. Most of the development of ultracentrifugation applications for molecular assembly and phage morphogenesis research was also performed in Fumio's laboratory. Fumio is a pioneer of supramolecular protein assembly study, and his science continues in the research work of the approximately 150 people who had attended his final lecture at the Tokyo Institute of Technology.
有坂文雄教授是噬菌体研究领域的著名领军人物之一，尤其在蛋白质生物物理学和结构生物学领域。自主噬菌体形态发生是一个由亚基-亚基相互作用控制的自组装过程。基于这一原理，有坂研究了T4噬菌体尾部的组装和形态。他还通过X射线结构分析和使用冷冻电子显微镜的三维图像重建相结合的方法，提供了有关T4噬菌体的结构信息。分子组装和噬菌体形态发生研究中超离心应用的大部分发展工作也是在有坂的实验室完成的。有坂是超分子蛋白质组装研究的先驱，他的科学成果在约150名参加了他在东京工业大学最后一次讲座的人员的研究工作中得以延续。
