Weis Serge, Büttner Andreas
Division of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital and School of Medicine, Johannes Kepler University, Linz, Austria.
Department of Forensic Medicine, University of Rostock, Rostock, Germany.
Handb Clin Neurol. 2017;145:167-173. doi: 10.1016/B978-0-12-802395-2.00012-2.
Vitamin deficiency disorders display a wide variety of neurologic signs and symptoms, the pathogenesis of which is not clearly understood. Metabolic encephalopathies (hepatic, hypoglycemic, and uremic) have to be considered in the differential diagnosis of patients with cognitive impairment, motor disturbances, psychiatric symptoms, seizures, and neuropathies. Calcifications (vascular wall and parenchymal) occur in the normal aging brain and in neurodegeneration; some associated genes are already described.
维生素缺乏症表现出各种各样的神经体征和症状，其发病机制尚不清楚。在对有认知障碍、运动障碍、精神症状、癫痫发作和神经病变的患者进行鉴别诊断时，必须考虑代谢性脑病（肝性、低血糖性和尿毒症性）。钙化（血管壁和实质）见于正常衰老大脑和神经退行性变中；一些相关基因已被描述。
