Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan Nepal, Nepal.
Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan Nepal, Nepal.
J Natl Med Assoc. 2017;109(3):198-202. doi: 10.1016/j.jnma.2017.01.009. Epub 2017 Mar 21.
Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Uric acid (UA) is filtered, reabsorbed and secreted by the kidney. Thus, this study was conducted to assess the serum UA levels in PIH and to evaluate the diagnostic value of serum UA level in PIH.
This is a hospital based comparative cross-sectional study conducted in BPKIHS. Ninety study participants were included; forty five participants were diagnosed of PIH and forty five in control group after obtaining informed consent from study participants from August 2014 to May 2015. Serum UA was done by Uricase method and serum creatinine was done by Jaffe's alkaline picrate method in cobas c311 autoanalyser. Data were expressed in frequency, percentage, mean ± S.D., median (IQR), and Independent t-test, Mann-Whitney U test were applied. p Value <0.05 is considered to be significant.
Mean serum UA levels was higher in PIH compared to control group (5.46 ± 1.51 vs 4.03 ± 0.69) respectively. ROC curve demonstrated that serum UA showed a superior diagnostic efficiency (Sensitivity - 79.07%, Specificity - 71.19%) compared to creatinine (Sensitivity - 62.75%, Specificity - 27.45%) in PIH respectively.
The present study shows that serum UA is significantly raised in PIH compared to the control group. Assessment of uric acid is a convenient and cost-effective method for determination of severity in PIH. Thus, serum uric acid can still be used as prevalent marker for risk assessment in PIH.
高血压是妊娠常见的医学并发症之一，对母婴围产期发病率和死亡率有重要影响。尿酸（UA）经肾脏滤过、重吸收和分泌。因此，本研究旨在评估妊娠高血压（PIH）患者的血清 UA 水平，并评估血清 UA 水平对 PIH 的诊断价值。
这是一项在 BPKIHS 进行的基于医院的比较性横断面研究。2014 年 8 月至 2015 年 5 月，在获得研究参与者的知情同意后，共纳入 90 名研究参与者，其中 45 名参与者被诊断为 PIH，45 名参与者为对照组。采用尿酸酶法检测血清 UA，采用 Jaffe 碱性苦味酸法检测血清肌酐，检测均在 cobas c311 自动分析仪上进行。数据以频率、百分比、均值±标准差、中位数（IQR）表示，采用独立 t 检验、Mann-Whitney U 检验。p 值<0.05 被认为具有统计学意义。
与对照组相比，PIH 患者的平均血清 UA 水平较高（5.46±1.51 与 4.03±0.69 相比）。ROC 曲线显示，血清 UA 比肌酐（灵敏度分别为 79.07%和 62.75%，特异性分别为 71.19%和 27.45%）具有更高的诊断效率。
本研究表明，与对照组相比，PIH 患者的血清 UA 显著升高。UA 的评估是一种方便、经济有效的方法，可用于确定 PIH 的严重程度。因此，血清尿酸仍然可以作为 PIH 风险评估的流行标志物。
