Division of Gastroenterology and Hepatology, Northwestern University, 676 North Saint Clair, Suite 1400, Chicago, IL 60611, USA.
Division of Gastroenterology and Hepatology, Northwestern University, 676 North Saint Clair, Suite 1400, Chicago, IL 60611, USA.
Clin Liver Dis. 2017 Nov;21(4):793-813. doi: 10.1016/j.cld.2017.06.006. Epub 2017 Aug 8.
The focus in liver transplantation in the next 10 years will likely change from preventing viral disease recurrence to minimizing the toll of rejection and fatty liver disease, minimizing the complications from immunosuppression with withdrawal strategies, and more optimal management of long-term risks, such as malignancy, cardiovascular disease, and renal failure. In addition, now that short-term results (<1 year) have improved significantly, there will be a shift toward improving long-term patient and graft survival, as well as a focus on primary care preventive strategies.
在未来 10 年内,肝移植的重点可能会从预防病毒疾病复发转移到最大限度地减少排斥反应和脂肪肝疾病的影响,通过撤药策略最大限度地减少免疫抑制的并发症,并更好地管理长期风险,如恶性肿瘤、心血管疾病和肾衰竭。此外,由于短期结果(<1 年)已显著改善,将转向提高患者和移植物的长期存活率,并关注初级保健预防策略。