INSERM U894, service d'imagerie morphologique et fonctionnelle, hôpital Sainte-Anne, université Paris Descartes, 1, rue Cabanis, 75014 Paris, France; Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Boston, Harvard Medical School, 02114 Boston, MA, USA.
INSERM U894, service d'imagerie morphologique et fonctionnelle, hôpital Sainte-Anne, université Paris Descartes, 1, rue Cabanis, 75014 Paris, France.
Rev Neurol (Paris). 2017 Nov;173(9):554-561. doi: 10.1016/j.neurol.2017.09.004. Epub 2017 Oct 4.
Cerebral amyloid angiopathy (CAA) is a frequent age-related small vessel disease (SVD) with cardinal magnetic resonance imaging (MRI) signatures that are hemorrhagic in nature, and include the presence of strictly lobar (superficial) cerebral microbleeds and intracerebral hemorrhages as well as cortical superficial siderosis. When investigating a patient with suspected CAA in the context of intracranial hemorrhage (parenchymal or subarachnoid) or cognitive dysfunction, various MRI parameters influence the optimal detection and characterization (and prognostication) of this frequent SVD. The present report describes the influence of imaging techniques on the detection of the key hemorrhagic CAA imaging signatures in clinical practice, in research studies, and the imaging parameters that must be understood when encountering a CAA patient, as well as reviewing CAA literature.
脑淀粉样血管病（Cerebral Amyloid Angiopathy，CAA）是一种常见的与年龄相关的小血管疾病（Small Vessel Disease，SVD），其主要的磁共振成像（Magnetic Resonance Imaging，MRI）特征为出血性，包括严格的脑叶（表浅）性脑微出血和脑实质出血以及皮质表面含铁血黄素沉着。当在颅内出血（脑实质或蛛网膜下腔）或认知功能障碍的背景下怀疑为 CAA 患者时，各种 MRI 参数会影响对这种常见的 SVD 的最佳检测和特征描述（以及预后判断）。本报告描述了影像学技术对临床实践、研究中关键出血性 CAA 影像学特征的检测的影响，以及在遇到 CAA 患者时必须了解的影像学参数，并回顾了 CAA 的文献。
