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局部麻醉下 ASAIII 患者椎体转移瘤经皮冷冻消融术的可行性。

Feasibility of percutaneous cryoablation of vertebral metastases under local anaesthesia in ASAIII patients.

机构信息

"ARNAS" Garibaldi Hospital, Department of Interventional Radiology, Via Francesco Crispi 4, Belpasso 95032, CT, Italy.

"ARNAS" Garibaldi Hospital, Department of Interventional Radiology, Piazza S. Maria di Gesù 4, Catania 95100, CT, Italy.

出版信息

Eur J Radiol. 2017 Oct;95:13-17. doi: 10.1016/j.ejrad.2017.07.011. Epub 2017 Jul 23.

Abstract

PURPOSE

spine metastases are common concern from several primary neoplasms, modern management include percutaneous techniques such as ablation and cementoplasty. This research aims to evaluate the treatment under local anaesthesia in high-risk patients (ASA III).

METHODS AND MATERIAL

from January 2013 up to September 2016 we treated via percutaneous cryoablation 11 advanced oncological patients classified as ASA III, then retrospectively a review of their clinical history has been performed. Interventions were managed under local anaesthesia, injecting low doses of bupivacaine 2,5mg/ml (from10 to 30ml). Cryoprobes of 17G were introduced under CT guidance. VAS scores were evaluated pre, intra and post operative up to the 3rd month and further, statistical analyses were obtained using T student test.

RESULTS

thirteen spinal metastases were cryoablated in 11 patients (6W, 5M; mean age of 53 years, range 52-81). Tumour location was: sacrum (n=6), lumbar spine (n=3), thoracic spine (n=2). The average VAS value during the procedure was 5,27 (standard deviation 0,90). There were statistically significant decreases in the median numeric VAS scale score at 1-week, 1-month, and 3-month time points (P<.001 for all). Technical success was achieved in all cases. Among patients with neurological deficit, some clinical improvement was assessed.

CONCLUSION

cryoablation with or without subsequent cement injection can be safely performed with local anaesthesia for pain relief also in patients with high ASA score with higher risk of complications, in the absence of any other suitable treatment.

摘要

目的

脊柱转移瘤是多种原发性肿瘤的常见问题,现代治疗方法包括经皮消融技术,如消融和骨水泥成形术。本研究旨在评估局部麻醉下对高危患者(ASA III 级)的治疗效果。

方法和材料

从 2013 年 1 月至 2016 年 9 月,我们对 11 例 ASA III 级晚期肿瘤患者进行了经皮冷冻消融治疗,然后对他们的临床病史进行了回顾性分析。手术均在局部麻醉下进行,注射低剂量布比卡因(2.5mg/ml,10-30ml)。在 CT 引导下引入 17G 冷冻探针。在术前、术中及术后 3 个月内评估 VAS 评分,进一步采用 T 检验进行统计学分析。

结果

11 例患者(6 例女性,5 例男性;平均年龄 53 岁,范围 52-81 岁)共 13 个脊柱转移瘤接受了冷冻消融治疗。肿瘤位置为:骶骨(n=6),腰椎(n=3),胸椎(n=2)。手术过程中 VAS 平均评分为 5.27(标准差 0.90)。1 周、1 个月和 3 个月时,中位数数字 VAS 评分均有显著下降(均 P<.001)。所有病例均获得技术成功。在有神经功能障碍的患者中,评估到一些临床改善。

结论

冷冻消融术联合或不联合随后的骨水泥注射,在没有其他合适治疗方法的情况下,可安全地在局部麻醉下进行,以缓解疼痛,也适用于 ASA 评分较高、并发症风险较高的患者。

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