Clinical pharmacology Department, Faculty of Medicine, Mansoura University, 35516, Egypt.
Pathology Department, Faculty of Medicine, Mansoura University, 35516, Egypt.
Biomed Pharmacother. 2017 Dec;96:215-221. doi: 10.1016/j.biopha.2017.09.136. Epub 2017 Oct 6.
Previous studies on simvastatin use in experimental schistosomiasis in mice did not provide a full explanation of its mechanism as antischisome. In this study, we tried to find out the role of IL-10 in the mechanism of action of simvastatin. We used 50 clear mice. Ten were used as normal not treated while 40 were infected with shistosome mansoni then divided into 4 groups; 3 treated groups by praziquantel, simvastatin and combined (praziquantel plus simvastatin) respectively and one group non-treated. The simvastatin treated group showed shortening and loss of the tubercles and disappearance of the spines with swelling and twisted shape of the worms. In addition, it also showed mitigation of ovideposition activity of the worms in the liver and reduction of the fibrous component of the liver granuloma producing a protective effect on the liver. This effect was associated with lowering of IL-10. This may explain the role of IL-10 in the protective effect of simvastatin. Combination of treatment with simvastatin plus praziquantel produced more significant effects in different parameters compared with praziquantel treated group. We recommend using simvastatin as add on therapy to standard antischistosomal therapy, praziquantel. Both drugs affect the worm motility and sucker activity and the ova deposition. Simvastatin has an additional pleiotropic effect halting inflammation and decreasing fibrosis due to increasing IL-10 leading to a hepatoprotective effect. Further clinical studies are needed to further validate these findings.
先前关于辛伐他汀在实验性曼氏血吸虫病小鼠中的应用的研究并没有完全解释其作为抗血吸虫药物的作用机制。在本研究中，我们试图探讨白细胞介素 10（IL-10）在辛伐他汀作用机制中的作用。我们使用了 50 只清洁小鼠。其中 10 只为正常未处理组，40 只为曼氏血吸虫感染组，然后分为 4 组；3 组分别用吡喹酮、辛伐他汀和联合（吡喹酮加辛伐他汀）治疗，1 组未治疗。辛伐他汀治疗组显示出结节缩短和丧失，棘消失，虫体肿胀扭曲。此外，它还减轻了肝内虫卵的产卵活性，并减少了肝肉芽肿的纤维成分，对肝脏产生了保护作用。这种作用与白细胞介素 10 的降低有关。这可能解释了白细胞介素 10 在辛伐他汀保护作用中的作用。与吡喹酮治疗组相比，辛伐他汀联合治疗在不同参数上产生了更显著的效果。我们建议将辛伐他汀作为标准抗血吸虫药物吡喹酮的附加治疗药物。这两种药物都影响虫体的运动和吸盘活性以及虫卵的沉积。辛伐他汀具有额外的多效性作用，通过增加白细胞介素 10 来阻止炎症和减少纤维化，从而产生肝保护作用。需要进一步的临床研究来进一步验证这些发现。
