Dermatological Students Scientific Association, Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.
Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.
Cells. 2023 Dec 4;12(23):2766. doi: 10.3390/cells12232766.
Interleukin 37 (IL-37) is a recently discovered member of the IL-1 cytokine family that appears to have anti-inflammatory and immunosuppressive effects in various diseases. IL-37 acts as a dual-function cytokine, exerting its effect extracellularly by forming a complex with the receptors IL-18 α (IL-18Rα) and IL-1R8 and transmitting anti-inflammatory signals, as well as intracellularly by interacting with Smad3, entering the nucleus, and inhibiting the transcription of pro-inflammatory genes. Consequently, IL-37 is linked to IL-18, which plays a role in the pathogenesis of atopic dermatitis (AD), consistent with our studies. Some isoforms of IL-37 are expressed by keratinocytes, monocytes, and other skin immune cells. IL-37 has been found to modulate the skewed T helper 2 (Th2) inflammation that is fundamental to the pathogenesis of AD. This review provides an up-to-date summary of the function of IL-37 in modulating the immune system and analyses its potential role in the pathogenesis of AD. Moreover, it speculates on IL-37's hypothetical value as a therapeutic target in the treatment of AD.
白细胞介素 37（IL-37）是最近发现的白细胞介素 1 细胞因子家族的成员，它在各种疾病中似乎具有抗炎和免疫抑制作用。IL-37 作为一种双功能细胞因子，通过与受体白细胞介素 18α（IL-18Rα）和白细胞介素 1R8 形成复合物并传递抗炎信号，以及通过与 Smad3 相互作用、进入细胞核并抑制促炎基因的转录来发挥细胞内作用。因此，IL-37 与白细胞介素 18（IL-18）有关，后者在特应性皮炎（AD）的发病机制中起作用，这与我们的研究一致。一些 IL-37 同工型由角质形成细胞、单核细胞和其他皮肤免疫细胞表达。已经发现 IL-37 可调节特应性皮炎发病机制中基本的偏斜辅助性 T 细胞 2（Th2）炎症。本综述提供了 IL-37 调节免疫系统功能的最新概述，并分析了其在 AD 发病机制中的潜在作用。此外，它推测了 IL-37 作为 AD 治疗的治疗靶点的假设价值。
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