Fachbereich Chemie, Philipps-Universität Marburg, Marburg, Germany.
Trends Endocrinol Metab. 2017 Nov;28(11):761-770. doi: 10.1016/j.tem.2017.09.003. Epub 2017 Oct 5.
Cytochrome c oxidase (CcO) is the final oxygen accepting enzyme complex (complex IV) of the mitochondrial respiratory chain. In contrast to the other complexes (I, II, and III), CcO is highly regulated via isoforms for six of its ten nuclear-coded subunits, which are differentially expressed in species, tissues, developmental stages, and cellular oxygen concentrations. Recent publications have claimed that NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (NDUFA4), originally identified as subunit of complex I, represents a 14th subunit of CcO. Results on CcO composition in tissues from adult animals and the review of data from recent literature strongly suggest that NDUFA4 is not a 14th subunit of CcO but may represent an assembly factor for CcO or supercomplexes (respirasomes) in mitochondria of growing cells and cancer tissues.
细胞色素 c 氧化酶（CcO）是线粒体呼吸链的最终氧接受酶复合物（复合物 IV）。与其他复合物（I、II 和 III）相比，CcO 通过其十个核编码亚基中的六个的同工型进行高度调节，这些同工型在物种、组织、发育阶段和细胞氧浓度中具有不同的表达。最近的出版物声称，NADH 脱氢酶（泛醌）1α亚基 4（NDUFA4）最初被鉴定为复合物 I 的亚基，代表 CcO 的第 14 个亚基。来自成年动物组织的 CcO 组成的结果以及对来自最近文献的数据的综述强烈表明，NDUFA4 不是 CcO 的第 14 个亚基，但可能代表生长细胞和癌细胞线粒体中的 CcO 或超复合物（呼吸体）的组装因子。
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